Example sentences for: deneddylation

How can you use “deneddylation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Our study also provides some insight into the role of deneddylation in cullin function, as we were able to create a situation in which Pcu1p and Pcu3p are fully neddylated in vivo (ref [ 10] and data presented here).

  • This mutant accumulates Pcu1p exclusively in a form carrying the stimulatory Nedd8p modification, due to a defect in COP9/signalosome-mediated cullin deneddylation [ 24 25 ] . Replacing wild-type ubiquitin by a mutant lacking all lysine residues prevented the formation of high molecular weight products (Fig.

  • 2C, 2D), where both cullins seem constitutively neddylated, argues against a critical role for dynamic cycles of neddylation and deneddylation in cullin function in fission yeast.

  • The results presented here eliminate the attractive hypothesis that the cysteine box in Csn5p, which is conserved in numerous deubiquitylating enzymes [ 23], harbors a critical activity for deneddylation (Fig.

  • So far, we were unable to obtain deneddylation of Pcu3p-13Myc in vitro by partially purified CSN preparations active in deneddylation of Pcu1p-13Myc (data not shown).


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