Example sentences for: deficiency

How can you use “deficiency” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Normal levels of labeled intermediates were observed from C16 to C4 without evidence for translocase deficiency or any other type of fatty acid oxidation disorder.

  • 8, abnormal less than 100) leading to the diagnosis of sucrase-isomaltase deficiency.

  • The mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) maps to chromosome location 6q25-27 [ 14 ] ; a chromosomal region predicted to contain a head and neck tumor suppressor gene [ 10 11 ] . It encodes for a receptor that functions in intracellular lysosomal enzyme trafficking, transforming growth factor beta activation, and IGF2 degradation (reviewed in [ 15 16 ] ). Granzyme B internalization by the M6P/IGF2R is also required for cytotoxic T cells to induce apoptosis in cells targeted for death, resulting in this receptor being referred to as a "death receptor" [ 17 ] . Elevated IGF2 levels during murine development arising from M6P/IGF2R deficiency result in cardiac abnormalities, cleft palate, fetal overgrowth and perinatal lethality [ 15 18 ] . Furthermore, large offspring syndrome frequently observed in cloned animals is associated with epigenetic changes in gene regulation and decreased M6P/IGF2R expression [ 19 ] . Thus, the M6P/IGF2R plays a crucial role in regulating mammalian fetal growth and development.

  • Several members of the ATP-binding cassette (ABC) superfamily, such as Abca1, are induced via PPARγ and LXRα activation [ 63 ] . Abca1 has been shown to play a role in reverse cholesterol pathways and may be linked to HDL deficiency in metabolic syndromes [ 64 ] . In macrophages, 18:2n6 and AA increased ABCA1 protein degradation without affecting transcriptional levels [ 65 ] . In the current study, Abca1 was significantly decreased by FUNG and FISH.

  • Streptozotocin injection led to reduced body weight and adiposity in sham-operated animals as previously described [ 5 17 ] (Table 2), whereas adrenalectomy attenuated the loss of both body weight and adiposity associated with insulin deficiency (Table 2).


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