Words similar to deficient
Example sentences for: deficient
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The tumor suppressor gene PTEN (also called MMAC1) has been found deleted or mutated in a great variety of human tumors and tumor cell lines [ 1 2 3 ] , and its tumor suppressing function has been confirmed in several in vitro studies [ 4 5 6 7 8 9 10 ] . Mice which are homozygously deficient in wild-type PTEN die during embryonic development and harbor regions of increased cellular proliferation, whereas heterozygous mice are viable but spontaneously develop tumors of various origins [ 11 12 ] .
We found that when A. baumannii was grown in iron deficient medium, IROMPs were expressed on their outer membranes with molecular weight of 88, 84, 80 and 77 kDa.
To test whether PLCγ2 is required for Btk:ER-induced calcium mobilization, parental and PLCγ2-deficient cells expressing Btk:ER were treated with 4-HT and/or anti-μ, or ionomycin as a positive control (Fig 4B).
Twenty-four hours after 4-HT treatment, apoptosis was detected in WT but not in PLCγ2-deficient cells (Fig 5C).
Although syk -deficient mice die perinatally, analysis of radiation chimeras reconstituted with fetal liver from syk -deficient mice has demonstrated a block in the transition from proB cells to preB cells, indicating that signal transduction through Syk is required for early B cell development [ 35 36 ] . Inactivation of the syk gene in the chicken DT40 B cell lymphoma leads to a loss in the activation of PLCγ2, the increase in intracellular free Ca 2+and the apoptotic response following engagement of the BCR.
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