Words similar to deacetylases
Example sentences for: deacetylases
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MeCP2's functional structure consists of an 84 amino acid methyl-binding domain (MBD) [ 11 ] and a 104 amino acid transcriptional repression domain (TRD) [ 12 ] . The MBD is able to bind to 5-methyl cytosine residues of a single CpG dinucleotide [ 11 ] . Under the current model, MeCP2 binds to DNA, then complexes with Sin3A through the TRD and recruits histone deacetylases (HDAC).
One way by which Smad7 can inhibit TGFβ-dependent gene expression is by blocking phosphorylation, and, hence, nuclear import of Smad3 and Smad2 [ 23 ] . More recent data showing that Smad7 is able to interact with histone deacetylases suggest an additional role for Smad7 as a transcriptional co-repressor [ 50 ] . Thus, Smad7 might interfere directly with Ese-1/Esx gene transcription.
Other enzymes, such as deacetylases and phosphatases, remove covalent modifications from proteins and thus reverse their effects [ 4, 5, 6].
The proto-oncogene TEL (Translocation, Ets, Leukemia) is a transcriptional repressor that contains a C-terminal Ets family DNA binding domain; a central domain that together with co-repressors recruit histone deacetylases [ 1 2 3 ] ; and an N-terminal SAM (sterile, alpha, motif) domain [ 4 5 6 ] , which we have recently shown forms a polymer [ 7 ] . Chromosomal translocations in a variety of leukemias result in fusion of the SAM domain of TEL to tyrosine kinase domains such as ABL, PDGFβ and JAK2 [ 8 9 10 11 12 13 14 ] or to the transcriptional activators AML1 and ARNT [ 15 16 17 ] . In the tyrosine kinase fusions, SAM domain polymerization leads to constitutive activation of the tyrosine kinase domains, which leads in turn to cell transformation [ 10 12 18 19 ] . Thus, compounds that block TEL-SAM polymerization could be effective in treating these leukemias.
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