Words similar to deacetylase
Example sentences for: deacetylase
How can you use “deacetylase” in a sentence? Here are some example sentences to help you improve your vocabulary:
Histone acetylation and p53 mutation appear not to be correlated in this study; nevertheless, it is necessary and more sensitive to examine histone acetylase and deacetylase activities in correlation to p53 status.
A PSI-BLAST search started with the N-terminal SBHM from the Aquifex aeolicus DDRP β' subunit detected several SBHMs from proteins other than the β' subunit, such as acetylornithine deacetylase (E = 2 × 10 -7, iteration 2), the C-terminal region of bacterial cytochrome F (E = 10 -4, iteration 2), biotin carboxyl carrier domain of biotin transcarboxylases (E = 6 × 10 -4, iteration 2) and the phosphotransferase system enzyme II (E = 10 -3, iteration 2).
Studies have shown BRCA1 is upregulated in cells treated by DNA damaging agents such as cisplatinum [ 4 ] . BRCA1 has been shown to interact with DNA repair proteins such as Rad50 and Rad51, the tumor suppressor genes RB and BRCA2, transcriptional factors (RNA pol II, histone deacetylase complex, ctIP) as well as influence numerous cyclins and cyclin dependent kinases contributing to cell cycle regulation [ 5 6 7 8 9 10 11 12 ] . More recently, BRCA1 has been shown to influence apoptosis in a p53 independent manner [ 13 ] . This apoptotic response involved the c-jun kinase (JNK) pathway, though the details of this mechanism remain unclear [ 14 ] .
Sir2 (the mammalian homolog is SIRT1) is a nicotinamide-adenine-dinucleotide-dependent histone deacetylase that interacts with numerous transcription factors to silence gene transcription.
SAHA was reported to be a histone deacetylase inhibitor and caused accumulation of hyperacetylated histone H4 in murine erythroleukemia [ 17].
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