Example sentences for: deacetylase

How can you use “deacetylase” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Sir2 (the mammalian homolog is SIRT1) is a nicotinamide-adenine-dinucleotide-dependent histone deacetylase that interacts with numerous transcription factors to silence gene transcription.

  • Studies have shown BRCA1 is upregulated in cells treated by DNA damaging agents such as cisplatinum [ 4 ] . BRCA1 has been shown to interact with DNA repair proteins such as Rad50 and Rad51, the tumor suppressor genes RB and BRCA2, transcriptional factors (RNA pol II, histone deacetylase complex, ctIP) as well as influence numerous cyclins and cyclin dependent kinases contributing to cell cycle regulation [ 5 6 7 8 9 10 11 12 ] . More recently, BRCA1 has been shown to influence apoptosis in a p53 independent manner [ 13 ] . This apoptotic response involved the c-jun kinase (JNK) pathway, though the details of this mechanism remain unclear [ 14 ] .

  • Thus, histone deacetylase inhibitors - Butyrate and Trichostatin A - can rescue MHCII-inducibility in bladder carcinoma cells [ 14 ] and restore constitutive MHCII expression in plasmacytoma cells [ 35 ] . In addition to acetylation, transcriptional activity of chromatin is also regulated through phosphorylation (reviewed in Ref.

  • Histone acetylation and p53 mutation appear not to be correlated in this study; nevertheless, it is necessary and more sensitive to examine histone acetylase and deacetylase activities in correlation to p53 status.

  • We also found evidence that promoter methylation inactivates gene expression in CC and exposure to methylation and/or histone deacetylase (HDAC)-inhibiting agents reactivate the gene expression.

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