Example sentences for: deacetylase

How can you use “deacetylase” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • We also found evidence that promoter methylation inactivates gene expression in CC and exposure to methylation and/or histone deacetylase (HDAC)-inhibiting agents reactivate the gene expression.

  • Studies have shown BRCA1 is upregulated in cells treated by DNA damaging agents such as cisplatinum [ 4 ] . BRCA1 has been shown to interact with DNA repair proteins such as Rad50 and Rad51, the tumor suppressor genes RB and BRCA2, transcriptional factors (RNA pol II, histone deacetylase complex, ctIP) as well as influence numerous cyclins and cyclin dependent kinases contributing to cell cycle regulation [ 5 6 7 8 9 10 11 12 ] . More recently, BRCA1 has been shown to influence apoptosis in a p53 independent manner [ 13 ] . This apoptotic response involved the c-jun kinase (JNK) pathway, though the details of this mechanism remain unclear [ 14 ] .

  • Sir2 (the mammalian homolog is SIRT1) is a nicotinamide-adenine-dinucleotide-dependent histone deacetylase that interacts with numerous transcription factors to silence gene transcription.

  • It was reported that some agents, e.g. histone deacetylase inhibitors [ 14 ] or DNA methylation inhibitors [ 15 ] , can rescue the IFNg inducibility of MHCII in cultured tumor cells.

  • We therefore suggest that the dose and time regimen for histone deacetylase inhibitors, such as SAHA, may have to consider the p53 status of breast cancers.


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