Example sentences for: deacetylase

How can you use “deacetylase” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Histone acetylation and p53 mutation appear not to be correlated in this study; nevertheless, it is necessary and more sensitive to examine histone acetylase and deacetylase activities in correlation to p53 status.

  • 4B) were examined to identify the potency of SAHA as a histone deacetylase inhibitor on mammary epithelial cells.

  • We therefore suggest that the dose and time regimen for histone deacetylase inhibitors, such as SAHA, may have to consider the p53 status of breast cancers.

  • Sir2 (the mammalian homolog is SIRT1) is a nicotinamide-adenine-dinucleotide-dependent histone deacetylase that interacts with numerous transcription factors to silence gene transcription.

  • Thus, histone deacetylase inhibitors - Butyrate and Trichostatin A - can rescue MHCII-inducibility in bladder carcinoma cells [ 14 ] and restore constitutive MHCII expression in plasmacytoma cells [ 35 ] . In addition to acetylation, transcriptional activity of chromatin is also regulated through phosphorylation (reviewed in Ref.


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