Example sentences for: ddrps
How can you use “ddrps” in a sentence? Here are some example sentences to help you improve your vocabulary:
Of these, four subunits, which correspond to the bacterial α, β, β' and ω, are universally present in all cellular DDRPs and constitute the conserved DDRP core [ 7 ] . Orthologs of the β and β' subunits are also encoded in the genomes of several families of large eukaryotic DNA viruses [ 33 34 35 ] . Biochemical studies have shown that the catalytic site of DDRP resides in the β' subunit and contains three invariant aspartates that coordinate a Mg 2+cation [ 22 23 24 36 ] . Recent structural analyses demonstrated that the core of DDRP is assembled around the β and β' subunits, which interact with each other to form a positively charged nucleic-acid-binding cleft.
Mirroring the insertion of the ASCR domain in the β' subunit, a distinct α + β globular domain, N-terminal to the DPBB domain (region 578-632 of 1K83, Chain B), is inserted in the β subunits of all archaeal and eukaryotic DDRPs (Fig.
Thus, several duplication-divergence events apparently preceded the emergence of the forms of these domains that are seen in the catalytic core of DDRPs (e.g.
The β' subunit of bacterial DDRPs contains a single Zn-ribbon at the N-terminus (region 56-81 of Thermus β' subunit; Fig.
Previously, AT-hooks have been detected primarily in eukaryotic chromatin-associated proteins, particularly transcription factors, where they function as accessory DNA-binding domains [ 74 ] . The ubiquity of the AT-hook-like modules in the β' subunits of DDRPs suggests that they were recruited for nucleic acid recognition in LUCA if not earlier.
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