Example sentences for: ddrps
How can you use “ddrps” in a sentence? Here are some example sentences to help you improve your vocabulary:
In the eukaryotic DDRP complex, these subunits occupy a spatial position very similar to that of the α-subunit homodimer of the bacterial DDRPs.
The orthologous largest subunits of the archaeal and eukaryotic DDRPs have two Zn-ribbons in the N-terminal portion of the protein (regions 59-88 and 103-173 in the yeast protein).
The wide spread in different phylogenetic lineages of two other SBHM domains, namely those found in dihydrolipoamide acetyltransferase and the glycine-cleaving enzyme, is indicative of their presence in LUCA [ 76 ] . The SBHM of the DDRPs is specifically related to the biotin/lipoate-binding SBHMs.
Of these, four subunits, which correspond to the bacterial α, β, β' and ω, are universally present in all cellular DDRPs and constitute the conserved DDRP core [ 7 ] . Orthologs of the β and β' subunits are also encoded in the genomes of several families of large eukaryotic DNA viruses [ 33 34 35 ] . Biochemical studies have shown that the catalytic site of DDRP resides in the β' subunit and contains three invariant aspartates that coordinate a Mg 2+cation [ 22 23 24 36 ] . Recent structural analyses demonstrated that the core of DDRP is assembled around the β and β' subunits, which interact with each other to form a positively charged nucleic-acid-binding cleft.
For example, the domain from the yeast β' subunit hit the α-subunits of bacterial DDRPs with Z-scores of 5-7 and RMSD of 2.8-3 Å. Hereinafter we refer to these domains as the α -subunit core-related (ASCR) domains.
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