Example sentences for: ddrps

How can you use “ddrps” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Thus, several duplication-divergence events apparently preceded the emergence of the forms of these domains that are seen in the catalytic core of DDRPs (e.g.

  • Previously, AT-hooks have been detected primarily in eukaryotic chromatin-associated proteins, particularly transcription factors, where they function as accessory DNA-binding domains [ 74 ] . The ubiquity of the AT-hook-like modules in the β' subunits of DDRPs suggests that they were recruited for nucleic acid recognition in LUCA if not earlier.

  • Of these, four subunits, which correspond to the bacterial α, β, β' and ω, are universally present in all cellular DDRPs and constitute the conserved DDRP core [ 7 ] . Orthologs of the β and β' subunits are also encoded in the genomes of several families of large eukaryotic DNA viruses [ 33 34 35 ] . Biochemical studies have shown that the catalytic site of DDRP resides in the β' subunit and contains three invariant aspartates that coordinate a Mg 2+cation [ 22 23 24 36 ] . Recent structural analyses demonstrated that the core of DDRP is assembled around the β and β' subunits, which interact with each other to form a positively charged nucleic-acid-binding cleft.

  • Structural and evolutionary relationship between the catalytic domains of the RDRPs and the DDRPs

  • None of these additional SBHMs were detectable in the archaeal or eukaryotic DDRPs, either in sequence searches or in direct comparisons of the crystal structures.


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