Example sentences for: ddrp

How can you use “ddrp” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • However, the DPBBs from the two DDRP subunits are spatially juxtaposed in the DDRP crystal, with the catalytic cleft located between them.

  • Using the experimentally determined structure as a guide, we split the β and β' subunits of the Thermus thermophilus DDRP and the largest two subunits of the yeast DDRP into individual globular domains and investigated them by visual inspection of the topology, structural searches of the PDB database using the DALI program and iterative searches of the NR database using PSI-BLAST.

  • In the eukaryotic DDRP complex, these subunits occupy a spatial position very similar to that of the α-subunit homodimer of the bacterial DDRPs.

  • In contrast to the ubiquitous DDRP, cellular RDRPs that are involved in PTGS so far have been detected only in eukaryotes [ 1 26 ] . The PTGS phenomenon covers a variety of complementarity-dependent silencing pathways, such as RNA interference (RNAi) in animals and slime mold, co-suppression (silencing of transgene and the corresponding endogenous genes) and virus gene resistance in plants, and quelling in fungi, all of which share a common mechanism of RNA turnover [ 28 37 38 39 40 ] . Essentially, double-stranded (ds) RNA, which is formed in these processes, triggers the activation of a sequence-specific RNA degradation system, which targets homologous RNAs [ 41 42 ] . The dsRNA is broken down by the Dicer enzyme into 21-25 nucleotide (nt) fragments called small interfering RNA or siRNAs [ 43 44 45 ] . The siRNAs subsequently associate with a complex of proteins called RISC and target homologous RNA by serving as guides for multiple rounds of RNA cleavage [ 45 46 ] .

  • Two of these SBHMs (regions 163-195 and 369-419 in 1iw7 chain D) are involved in the interaction with the σ 70 subunit, which is critical for transcription initiation in bacteria [ 23 ] . Thus, it appears likely that, originally, the SBHM domain of the β subunit participated in generic protein-protein interactions that allowed the ancestral DDRP to recruit accessory subunits.


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