Words similar to ddrp

Example sentences for: ddrp

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Examination of the recently solved structures of the DDRP showed that, although β' subunit is a large protein, the active site containing the DxDGD motif mapped to a small, compact β-barrel domain.
Although the major events in the evolution of polymerases occurred at very early stages of evolution and LUCA already had an advanced DDRP resembling the extant forms, subsequent lineage-specific elaborations of considerable magnitude have occurred.
Thus, it appears likely that the ancestral DDRP evolved from the coalescence of at least 3 distinct domains: i) the DPBB that probably originally bound RNA and, subsequently, segregated into the cores of the β' subunit, where it acquired the metal-coordinating active site, and of the β subunit, with the two lysines projecting into the catalytic cleft (Fig.
Given that DDRP is universal, whereas RDRP is eukaryote-specific, a plausible hypothesis might be that RDRP evolved at the onset of eukaryotic evolution through extensive, rapid sequence divergence following a duplication of the β' subunit of the ancestral DDRP.
Using the experimentally determined structure as a guide, we split the β and β' subunits of the Thermus thermophilus DDRP and the largest two subunits of the yeast DDRP into individual globular domains and investigated them by visual inspection of the topology, structural searches of the PDB database using the DALI program and iterative searches of the NR database using PSI-BLAST.