Words similar to ddrp

Example sentences for: ddrp

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The α subunit further stabilizes this cleft, whereas the ω subunit interacts with the β' subunit [ 7 ] . Given their ubiquitous presence in all cellular life forms and high level of sequence conservation, it seems evident that the core subunits of this complex RNA synthesis machine were already present in the last universal common ancestor (LUCA) of the extant cellular life forms and performed functions mechanistically similar to those of modern DDRP.
One possibility is that the RDRP module has emerged at the onset of the evolution of eukaryotes through extreme sequence divergence following a duplication of the DDRP β' subunit.
There is no evidence that the ASCR domain in the DDRP α-subunits binds nucleic acids and studies on SUI1 protein and the arginine repressor ligand-binding domain implicate the ASCR domain in protein-protein interactions and small molecule binding [ 77 79 ] . However, most of the ASCR domains are present in proteins that interact with nucleic acids (see above), raising the possibility of a role in non-specific nucleic acid binding.
The ancestral versions of these domains would not have the adaptations for specific roles possessed by their descendant forms, such as those in extant DDRP or RDRP, and probably functioned as generic RNA-binding and protein-protein interaction domains, with the specificity conferred by catalytic RNA molecules.
In principle, radical divergence could have eroded all similarity between RDRP and DDRP beyond the DPBB domain.