Example sentences for: ddrp
How can you use “ddrp” in a sentence? Here are some example sentences to help you improve your vocabulary:
Given that DDRP is universal, whereas RDRP is eukaryote-specific, a plausible hypothesis might be that RDRP evolved at the onset of eukaryotic evolution through extensive, rapid sequence divergence following a duplication of the β' subunit of the ancestral DDRP.
For example, searches seeded with the RDRP (RrpB gene product) sequence from Dictyostelium (gi:14475571) and the pattern [GAS]-D- [FLYMQN]-D- [G]-D-X- [ACLIVMFY]-X- [ACLIVMFY] detected the rice DDRP catalytic subunit with an E-value of 0.048.
The AT-hook is a simple, small protein module that consists of a flap-like structure with a positively charged surface that is inserted into the minor groove of DNA [ 74 ] . The two AT-hook-like modules (residues 583-603 of 1IW7 chain D) in the DDRP β' subunit are inserted within the α-helix that is located immediately upstream of the DPBB domain (Fig.
Two of these SBHMs (regions 163-195 and 369-419 in 1iw7 chain D) are involved in the interaction with the σ 70 subunit, which is critical for transcription initiation in bacteria [ 23 ] . Thus, it appears likely that, originally, the SBHM domain of the β subunit participated in generic protein-protein interactions that allowed the ancestral DDRP to recruit accessory subunits.
In contrast to the ubiquitous DDRP, cellular RDRPs that are involved in PTGS so far have been detected only in eukaryotes [ 1 26 ] . The PTGS phenomenon covers a variety of complementarity-dependent silencing pathways, such as RNA interference (RNAi) in animals and slime mold, co-suppression (silencing of transgene and the corresponding endogenous genes) and virus gene resistance in plants, and quelling in fungi, all of which share a common mechanism of RNA turnover [ 28 37 38 39 40 ] . Essentially, double-stranded (ds) RNA, which is formed in these processes, triggers the activation of a sequence-specific RNA degradation system, which targets homologous RNAs [ 41 42 ] . The dsRNA is broken down by the Dicer enzyme into 21-25 nucleotide (nt) fragments called small interfering RNA or siRNAs [ 43 44 45 ] . The siRNAs subsequently associate with a complex of proteins called RISC and target homologous RNA by serving as guides for multiple rounds of RNA cleavage [ 45 46 ] .
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