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Example sentences for: daocs

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The conserved portion of the 2OG-Fe(II) dioxygenase superfamily proteins comprises the core DSBH domain seen in the IPNS, DAOCS and CAS structures [ 8, 9, 10] and part of the amino-terminal α helix that showed considerable variability in both length and sequence between individual families (Figures 1, 2).
Using the secondary structure elements from the experimentally determined structures of IPNS (PDB:1ips), DAOCS (PDB:1dcs), CAS (PDB:1drt) and the predicted secondary structures for individual families, the conserved core of these elements was delineated (Figure 1).
The conservation of all the residues implicated in catalysis in the biochemically uncharacterized proteins such as AlkB, EGL-9, leprecan and YbiX suggests they all catalyze oxidative reactions similar to those catalyzed by IPNS, DAOCS, CAS and related enzymes such as protein lysyl/prolyl hydroxylases, EFE and leucoanthocyanidin oxidases [ 1, 2].
Similarly, fungi contain several enzymes involved in secondary metabolite biosynthesis, such as IPNS and DAOCS, that are distinctly related to their counterparts in actinomycetes.
The roles of all these conserved residues in catalysis are apparent from the crystal structures of IPNS, clavaminic acid synthase (CAS) and deacetoxycephalosporin C synthase (DAOCS) [ 8, 9, 10].