Words similar to cytolytic
Example sentences for: cytolytic
How can you use “cytolytic” in a sentence? Here are some example sentences to help you improve your vocabulary:
CD8 + cytolytic T lymphocytes (CTLs) are the primary effector cells of the adaptive immune system and have a major role in protecting us from a vast array of diseases including cancer.
Thus by inducing migration and interaction with EC, IL-12 regulates crucial determinants of NK cell recruitment in tissues [ 20 ] . It is believed that IL-12 plays an instrumental role in tilting the immune response in favor of T helper type 1 by generation of Th1 cells and consequently initiates CMI [ 28 ] . Since IL-12 enhances cytotoxicity and augments proliferation by antigen specific T cells and NK cells, IL-12 may facilitate antigen specific and nonspecific cytotoxic immune defense against intracellular pathogens such as M. tuberculosis . An intriguing property of IL-12 is its capacity to induce proliferation by cytolytic T cell only upon co-stimulation with antigen.
Thus, BAECs are particularly sensitive to the cytolytic effects of MTX.
The involvement of Rho GTPases in regulating integrin dependent events such as leukocyte homotypic aggregation and in chemokine upregulation of integrin-mediated adhesion has recently been identified [ 18 19 ] . ADP-ribosylation of Rho in neutrophils by treatment with C3 not only inhibits cellular locomotion, but augments chemoattractant induced actin polymerization [ 20 21 ] . Moreover, inactivation of Rho in monocytic cells leads to accelerated formation of filopodia, and it has been proposed that Rho is a negative regulator of actin polymerization within this cell type [ 22 ] . Active Rho is also required for normal morphology, motility, and cytolytic activity of IL-2 activated NK cells [ 23 24 ] . We and others have demonstrated the importance of Rho in T lymphocyte activation [ 25 26 ] . Given the role played by Rho in the regulation of actin microfilaments in other cell types, and the indispensability of a functional actin cytoskeleton in lymphocyte motility and activation, it is of importance to study Rho's role in the regulation of T lymphocyte integrin function and maintenance of cytoskeletal organization.
Recent studies have shown that maitotoxin (MTX), a potent cytolytic agent isolated from the dinoflagellate Gambierdiscus toxicus, is an important new molecular tool for the study of oncotic (necrotic) cell death [ 1 2 ] . In a variety of cell types, MTX initiates a cell death cascade that involves a sequence of cellular events essentially identical to those activated by stimulation of purinergic receptors of the P2Z/P2X 7 type.
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