Words similar to cytolytic
Example sentences for: cytolytic
How can you use “cytolytic” in a sentence? Here are some example sentences to help you improve your vocabulary:
NK cytolytic functions disappeared in estradiol-treated mice by 8 weeks.
The involvement of Rho GTPases in regulating integrin dependent events such as leukocyte homotypic aggregation and in chemokine upregulation of integrin-mediated adhesion has recently been identified [ 18 19 ] . ADP-ribosylation of Rho in neutrophils by treatment with C3 not only inhibits cellular locomotion, but augments chemoattractant induced actin polymerization [ 20 21 ] . Moreover, inactivation of Rho in monocytic cells leads to accelerated formation of filopodia, and it has been proposed that Rho is a negative regulator of actin polymerization within this cell type [ 22 ] . Active Rho is also required for normal morphology, motility, and cytolytic activity of IL-2 activated NK cells [ 23 24 ] . We and others have demonstrated the importance of Rho in T lymphocyte activation [ 25 26 ] . Given the role played by Rho in the regulation of actin microfilaments in other cell types, and the indispensability of a functional actin cytoskeleton in lymphocyte motility and activation, it is of importance to study Rho's role in the regulation of T lymphocyte integrin function and maintenance of cytoskeletal organization.
The large pores activated by MTX have been referred to as cytolytic/oncotic pores, or COP, since their activation ultimately leads to the release of lactate dehydrogenase (LDH), an indication of necrotic or oncotic cell death [ 9].
To distinguish between these two models, the effect of MTX on [Ca 2+] i , vital dye uptake and LDH release was examined in bovine aortic endothelial cells, a cell line particularly sensitive to the cytolytic effects of MTX.
Thus, BAECs are particularly sensitive to the cytolytic effects of MTX.
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