Words similar to cytolytic
Example sentences for: cytolytic
How can you use “cytolytic” in a sentence? Here are some example sentences to help you improve your vocabulary:
Recent studies have shown that maitotoxin (MTX), a potent cytolytic agent isolated from the dinoflagellate Gambierdiscus toxicus, is an important new molecular tool for the study of oncotic (necrotic) cell death [ 1 2 ] . In a variety of cell types, MTX initiates a cell death cascade that involves a sequence of cellular events essentially identical to those activated by stimulation of purinergic receptors of the P2Z/P2X 7 type.
IL-12 may thus be a candidate to control the cytolytic arm of initial immune response to pathogens by inducing expansion of cytotoxic T cell only when antigen is encountered [ 29 ] . The biologic significance of the multiplicity of cytokines which can stimulate the proliferation of T and NK cells is unclear.
Thus by inducing migration and interaction with EC, IL-12 regulates crucial determinants of NK cell recruitment in tissues [ 20 ] . It is believed that IL-12 plays an instrumental role in tilting the immune response in favor of T helper type 1 by generation of Th1 cells and consequently initiates CMI [ 28 ] . Since IL-12 enhances cytotoxicity and augments proliferation by antigen specific T cells and NK cells, IL-12 may facilitate antigen specific and nonspecific cytotoxic immune defense against intracellular pathogens such as M. tuberculosis . An intriguing property of IL-12 is its capacity to induce proliferation by cytolytic T cell only upon co-stimulation with antigen.
CD8 + cytolytic T lymphocytes (CTLs) are the primary effector cells of the adaptive immune system and have a major role in protecting us from a vast array of diseases including cancer.
The involvement of Rho GTPases in regulating integrin dependent events such as leukocyte homotypic aggregation and in chemokine upregulation of integrin-mediated adhesion has recently been identified [ 18 19 ] . ADP-ribosylation of Rho in neutrophils by treatment with C3 not only inhibits cellular locomotion, but augments chemoattractant induced actin polymerization [ 20 21 ] . Moreover, inactivation of Rho in monocytic cells leads to accelerated formation of filopodia, and it has been proposed that Rho is a negative regulator of actin polymerization within this cell type [ 22 ] . Active Rho is also required for normal morphology, motility, and cytolytic activity of IL-2 activated NK cells [ 23 24 ] . We and others have demonstrated the importance of Rho in T lymphocyte activation [ 25 26 ] . Given the role played by Rho in the regulation of actin microfilaments in other cell types, and the indispensability of a functional actin cytoskeleton in lymphocyte motility and activation, it is of importance to study Rho's role in the regulation of T lymphocyte integrin function and maintenance of cytoskeletal organization.
Loading...