Words similar to cyp
Example sentences for: cyp
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Experimental studies [ 21 22 ] have shown that the CYP17 polymorphism in the 5'-flanking region of the gene does not influence binding to Sp1, as previously conjectured [ 1 20 ] . Nonetheless, studies in both premenopausal women and postmenopausal women have found that those with A2 alleles have higher circulating levels of steroid hormones.
StAR plays a key role in the initial steps of steroidogenesis, because it is required for transport of cholesterol to the inner mitochondrial membrane where CYP11A1 resides and the first reaction in progesterone synthesis occurs [ 45 ] . cAMP is a well known second messenger in FSH- and LH-stimulated progesterone synthesis, and a key effect of the cAMP-dependent protein kinase in GC is transcriptional control of StAR [ 46 47 ] . Estradiol is recognized as a biological amplifier of basal, FSH- and cAMP-stimulated progesterone production in pig GC, with significant synergistic effects distal to the generation of cAMP at one or more steps in cholesterol transport and metabolism [ 48 ] . Our experimental results are thus consistent with 4-AP inhibition of GC progesterone output via drug effects on multiple interacting sites in the steroidogenic pathway.
Similar results were observed with the tandem DR-4 sites from the CYP2B10 gene, except that LG1069 did not have a significant stimulatory effect on its own, but did augment the effect of TCPOBOP.
Odds ratios and 95% confidence intervals were calculated using unconditional logistic regression to evaluate associations between CYP17 genotypes and breast cancer risk separately for premenopausal and post-menopausal women.
Hormonally related factors appeared to vary by CYP17 genotype (Table 1).
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