Words similar to cyp
Example sentences for: cyp
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The βRARE-TK-Luc reporter plasmid with three copies of the DR-5 motif from the promoter of the mouse RARβ2 gene has been described previously, as has the CYP2B10-TK-Luc reporter with two copies of the DR-4 type elements from the promoter of the mouse CYP2B10 gene and the CYP3A4-TK-luc reporter with three copies of the ER-6 element from the human CYP3A4 promoter [ 16 ] . Expression vectors for full length mCAR and RXR proteins were as described [ 9 ] . The cdm8-mCARΔ8 deletion construct containing a deletion of the last 8 amino acids and the mutant with 2 helix 3 mutations (F171L, I174A) that block ligand binding and response have been described previously [ 16 ] , as has the cdm8-RXRΔ19 construct with a deletion of the last 19 amino acids [ 3 ] .
A number of studies have evaluated possible associations between a polymorphism in the cytochrome P450c17α ( CYP17 ) gene and breast cancer risk [ 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 ] . Cytochrome P450c17α functions at key branch points in human steroidogenesis, catalyzing the ovarian and adrenal biosynthesis pathways for androstenedione, the immediate precursor of testosterone [ 17 ] . Three polymorphisms have been described in this gene: a C → T transition at nucleotide 5471 in intron 6 [ 18 ] , a G → A transition at nucleotide 47 in the 5'-untranslated region promoter [ 19 ] , and a thymidine substitution for cytosine at nucleotide 27 in the 5'-untranslated region promoter that creates a Msp AI recognition site [ 20 ] .
Finally, expression of the endogenous CYP2B6 gene in CAR expressing HepG2 cells is modestly inhibited by LG1069 alone, androstanol alone and the combination of both.
CYP2B6 expression was increased by TCPOBOP, as expected, and this response was blocked by LG1069 treatment.
Genes such as Cd36, Cyp2b9, Hmgcs2, and Ech1 were induced more than 4-fold when Wy-14,643 (a PPARα-specific agonist) was administered to mice for 2 weeks.
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