Words similar to cyclosome

Example sentences for: cyclosome

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The MATs are predicated upon the coordinated activities of the spindle checkpoint [ 16 17 ] , the anaphase-promoting complex (APC) or cyclosome [ 18 19 ] , the proteasome [ 20 21 ] , and the cohesion-complex proteins involved with chromosome cohesion and separation [ 22 23 24 ] . Alterations in the temporal sequence of these coordinated activities may potentially predispose cells to faulty chromosome segregation.
In S. cerevisiae, a key event accompanying exit from mitosis is the inactivation of Clb/Cdc28 protein kinase achieved through degradation of Clb and accumulation of the Clb/Cdc28 inhibitor Sic1 (reviewed in [ 1 ] ). Anaphase-Promoting Complex/Cyclosome (APC/C) ubiquitin ligase and its substrate specific activator Hct1/Cdh1 are required for degradation of Clb2, the major mitotic cyclin in the budding yeast (reviewed in [ 2 ] ). Whereas hct1Δ and sic1Δ cells appear relatively normal,