Words similar to cyclophosphamide
Example sentences for: cyclophosphamide
How can you use “cyclophosphamide” in a sentence? Here are some example sentences to help you improve your vocabulary:
All patients were treated with the FAC (fluorouracil, doxorubicin, cyclophosphamide) regimen that consisted of 50 mg/m 2doxorubicin given as a continuous infusion over 72 hours starting on day 1, 500 mg/m 2cyclophosphamide intravenously on day 1, and 500 mg/m 2fluorouracil intravenously on days 1 and 4. Treatment was given every 3 or 4 weeks for a total of six cycles.
Treatment of L1210/CPA cells in vitro with 50 μM DEAB abolished the tumor cells' resistance to 4-HC [ 19 ] . DEAB also exhibited in vivo efficacy as a ALDH1A1 inhibitor, as demonstrated by the toxicity to the intestinal crypt cells in mice receiving co-injections of DEAB and cyclophosphamide [ 21 ] . More recently, DEAB has been used to demonstrate that overexpression of human ALDH1A1 in transfected cell lines is sufficient to cause cellular resistance to the oxazaphosphorines [ 22 ] and 4-HC [ 23 ] . DEAB has also been an effective reagent in fluorescent-activated cell sorting (FACS) techniques to isolate human hematopoietic stem cells based on the expression of ALDH1A1 activity [ 5 6 ] . In contrast to DEAB and DPAB, daidzin - a natural product isolated from Pueraria lobata (the Kudzu plant) - shows specificity for inhibiting ALDH2 at concentrations similar to that of DPAB used to inhibit ALDH1A1 [ 24 25 ] . An inhibitor specific for ALDH1A2 has not yet been reported.
Seventeen ALDH genes have been identified in the human genome and have been classified into ten different families based on amino acid sequence identities [ 1 2 ] . High levels of ALDH1A1 activity can protect human and murine cells from the toxicity of the alkylating agent cyclophosphamide and its oxazaphosphorine analogs.
In Silber's patient sample, one-third of the patients were treated with the less myelosuppressive CMF (cyclophosphamide, methotrexate, fluorouracil) chemotherapy regimen, and the CAF (cyclophosphamide, doxorubicin, fluorouracil) regimen consisted of 30 mg/m 2compared with the 50 mg/m 2CAF regimen used in our validation sample.
Indeed it was hypothesized that the high expression of ALDH1A1 (formerly known as class 1 ALDH) was responsible for the successful use of cyclophosphamide in tumor cell purging regimens during bone marrow transplantation [ 3 ] . The detection of elevated ALDH1A1 activity in the most primitive human hematopoietic progenitor cells [ 4 5 6 ] has provided evidence in support of this hypothesis.
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