Words similar to cyclophosphamide
Example sentences for: cyclophosphamide
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Seventeen ALDH genes have been identified in the human genome and have been classified into ten different families based on amino acid sequence identities [ 1 2 ] . High levels of ALDH1A1 activity can protect human and murine cells from the toxicity of the alkylating agent cyclophosphamide and its oxazaphosphorine analogs.
ANC = absolute neutrophil count; CAF = chemotherapy with cyclophosphamide, doxorubicin, fluorouracil; MDACC = MD Anderson Cancer Center.
Treatment of L1210/CPA cells in vitro with 50 μM DEAB abolished the tumor cells' resistance to 4-HC [ 19 ] . DEAB also exhibited in vivo efficacy as a ALDH1A1 inhibitor, as demonstrated by the toxicity to the intestinal crypt cells in mice receiving co-injections of DEAB and cyclophosphamide [ 21 ] . More recently, DEAB has been used to demonstrate that overexpression of human ALDH1A1 in transfected cell lines is sufficient to cause cellular resistance to the oxazaphosphorines [ 22 ] and 4-HC [ 23 ] . DEAB has also been an effective reagent in fluorescent-activated cell sorting (FACS) techniques to isolate human hematopoietic stem cells based on the expression of ALDH1A1 activity [ 5 6 ] . In contrast to DEAB and DPAB, daidzin - a natural product isolated from Pueraria lobata (the Kudzu plant) - shows specificity for inhibiting ALDH2 at concentrations similar to that of DPAB used to inhibit ALDH1A1 [ 24 25 ] . An inhibitor specific for ALDH1A2 has not yet been reported.
AGCN = average gene copy number; CART = Classification and Regression Trees; CMF = cyclophosphamide, methotrexate, 5-fluorouracil; DFS = disease-free survival; NNBC = node-negative breast cancer; FEC = fluorouracil, epirubicin, cyclophosphamide; OS = overall survival; PCR = poly-merase chain reaction.
7% of patients; and chemotherapy (six cycles of cyclophosphamide, methotrexate, 5-fluorouracil [CMF] or four cycles of fluorouracil, epirubicin, cyclophosphamide [FEC]) in 33.
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