Words similar to creb
Example sentences for: creb
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These signaling pathways in turn, activate a variety of transcription factors including NF-kappaB (p50/p65), AP-1 (c-Fos/c-Jun), and CREB phosphorylation, which in turn coordinate the induction of many genes encoding inflammatory mediators.
Interestingly, three genes whose products are known to promote viral replication were associated with v- myb and v- abl oncogenes (shared terms: 'virus', 'transformation' or 'leukemia'): TAX1BP1 (Tax1-binding protein 1), CREB3 (cAMP-response element binding protein 3/LZIP) and TARBP2 (TAR-binding protein 2) (Figure 7a) [ 20, 21, 22].
In keeping with this notion, regulatory elements, within the CD4 and CD8 promoters have been identified an characterized including the presence of cAMP regulatory elements binding (CREB) sites [ 35 ] . However it is also likely that the control of CD4 and CD8 expression and thus the selection of CD4 or CD8 lineage-committed cells may also be controlled by the differences in mRNA and protein stability.
Binding reactions were carried out at room temperature for 30 min in a total volume of 15 μl and contained 2-5 μg of nuclear extracts, 5 μl of 5X gel shift binding buffer (20% glycerol, 5 mM MgCl 2 , 2.5 mM EDTA, 2.5 mM DTT, 250 mM NaCl, 50 mM Tris-HCl, pH 7.5), 2 μg poly (dI-dC) and 3 × 10 4cpm/μl of [ 32P] labeled CREB (5'-AGA GAT TGC CTG ACG TCA GAG AGC TAG-3'), NF-κB (5'-AGT TGA GGG GAC TTT CCC AGG C-3') (Promega Gel Shift Assay Systems, Madison, WI, USA) or CCAAT/enhancer binding protein (C/EBP) (5'-TGC AGA TTG CGC AAT CTG CA-3') (Santa Cruz Biotechnology, Inc., Santa Cruz, CA, USA) oligonucleotides.
The deleted region is not conserved in hTAF II 105 and dTAF II 110, is not involved in interactions with other TAF II s, SP1, or CREB [ 26, 27, 33], and has no known function.
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