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Example sentences for: creb

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These proteins could have a potentially important role in the regulation of cell growth, as TAX1BP, CREB3 and TARBP possess anti-apoptotic, tumor suppressor and oncogenic activities [ 23, 24, 25], respectively.
A common intermediate pathway initiating from receptors to the nucleus is the Ras/Raf/MEK/ERK (MAPK) cascade, which can result in the phosphorylation and activation of additional downstream kinases and transcription factors such as p90Rsk, CREB, Elk, and Egr-1 [ 55 56 ] . Therefore, it is intriguing that Tat expressing cells show down-regulation of MAPK components (Table 3, Figure 3Band 3C), essential mediators between receptors and nuclear transcription factors.
In transfected cells, subdomains of TAF II 135 can act as dominant negative repressors of CREB activity [ [ 26 27 28 ] ]. It has further been suggested that some neurodegenerative diseases may result from sequestration of TAF II 135 by expanded polyglutamine domains and consequent interference with CREB activity [ 29].
These findings are in accord with previous studies on mouse lung neutrophils during endotoxemia [ 21 ] . Our observation that nuclear binding activity appeared in the cells rapidly after endotoxin administration (within 0.5 hours) indicates that NF-κB and CREB are involved in early functional activation.
The deleted region is not conserved in hTAF II 105 and dTAF II 110, is not involved in interactions with other TAF II s, SP1, or CREB [ 26, 27, 33], and has no known function.