Words similar to crd
Example sentences for: crd
How can you use “crd” in a sentence? Here are some example sentences to help you improve your vocabulary:
DFz2, like other members of the Fz protein family, contains a cysteine-rich domain (CRD) near the aminoterminus, followed by a seven-transmembrane (7-TM) domain and a cytoplasmic carboxyterminal tail.
To determine which domains in DFz2 are important for its synergistic activity with Wg in the S2 cell assay, we deleted the regions encoding the CRD domain (DFz2ΔCRD) or the cytoplasmic tail (DFz2ΔC) in pPacPL (Figure 3A) and tested the deletion constructs shown in panel A in the luciferase assay described earlier (Figure 3B).
This effect requires the aminoterminus of DFz2, implying a requirement for binding Wg to the Fz CRD, but not the carboxyterminus, suggesting that the signal may be, in part, transmitted through an interaction of Wg-Frizzled complex with another protein.
DFz2 reportedly binds to Wg through its CRD domain [ 6 ] , but it is not known which proteins interact with the carboxyterminus or with cytoplasmic loops in the 7-TM region of DFz2 to transduce the signal to the cytoplasmic signaling component Dsh.
The synergy between Wg and DFz2 requires the CRD domain of DFz2, but not the carboxyterminus