Words similar to coupler
Example sentences for: coupler
How can you use “coupler” in a sentence? Here are some example sentences to help you improve your vocabulary:
Thus, in considering models of Ptc function based on Hh-stimulated effects it is important to consider whether the form of Smo that is being observed is the active (coupler/effector bound) signaling state, or perhaps a downregulated and inactive form.
Throughout the discussion the term 'coupler/effector' is used to describe an unknown molecule that binds activated Smo in such a way as to trigger signal transduction.
Tests on other locations of the dipole relative to the phantom (near the ear, the loop or the meander) showed no influence up to a maximum available radiation power of 6 W. The uncertainty of the transmitting power measurement was less than ± 30%, and is basically composed of the uncertainty of the power measurement itself and the uncertainty of the direction coupler parameters.
Briefly, if this model is applied to Hh signaling, it proposes that, firstly, agonist and antagonists act at independent sites to select active and inactive conformations of Smo; secondly, that Smo engages an undefined coupler/effector, when it is in its signaling state; and finally, that the gain-of-function mutant form of Smo, Smo act, adopts an abnormal conformation that resembles the coupler/effector-bound signaling state of Smo with low affinity for antagonists but normal affinity for the agonist.
The model further suggests that the Smo actprotein resides in a stable conformation in the absence of agonist that is capable of forming an active coupler/effector complex resistant to antagonist, but not agonist, binding.
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