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Example sentences for: coupled
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It has been described in the literature that a closer estimate of a physiological load-deformation in any specimen may only be obtained by applying pure moment, with six degrees of freedom, allowing coupled motion [ 22 ] However, it is expected that a constrained system would affect the load-deformation and the ROM patterns almost equally, for both the stabilization system.
The classical concentration-response relationship is depicted as a sigmoidal shaped curve, however, the particular shape of the concentration-response curve may differ for each coupled toxicant and response pair.
Ca 2+ , along with other second messengers, may influence the expression of genes encoding ion channels, allowing their expression to be coupled to neural activity (Berridge 1998) (Figure 1B and 1C).
The M6P/IGF2R is also mechanistically involved in the genesis of human cancer [ 6 20 21 22 23 24 ] . M6P/IGF2R loss of heterozygosity coupled with intragenic loss-of-function mutations in the remaining allele is a common event in human cancers [ 6 20 21 22 ] . Inheritance of a tandem repeat polymorphism in the 3' UTR of M6P/IGF2R furthermore predicts for enhanced susceptibility to oral cancer [ 25 ] . Moreover, tumor cell growth is inhibited when M6P/IGF2R expression is restored to normal while it is increased when gene expression is reduced [ 26 27 28 29 ] . The results of these mutational and functional studies clearly demonstrate that the M6P/IGF2R possesses the characteristics necessary to be classified as a tumor suppressor gene [ 30 ] .
PAR'S are G-coupled receptors activated by proteolytic cleavage of their exo-domains.
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