Words similar to corepressors
Example sentences for: corepressors
How can you use “corepressors” in a sentence? Here are some example sentences to help you improve your vocabulary:
A highly ordered chromatin structure presents a physical obstacle for gene transcription; presumably by limiting the access of transcription factors and RNA polymerase II core machinery to target DNA [ 82 83 ] . In concert with the observation that corepressors are associated with HDAC activities [ 84 85 ] , it appears that the transcriptional outcome of nuclear receptors is determined by the balance of histone acetylation and deacetylation activities, and that ligands serve as a switch to recruit HATs with the concomitant dismissal of HDACs.
Generally, NR transcriptional activity is dictated by the balance between coactivator and corepressor recruitment, and one of the most important factors that influences this balance is the absence or presence of agonist ligands (reviewed in [ 4 ] ). Unliganded NRs such as thyroid (TRs) and retinoid receptors (RARs) bind corepressors, and ligand promotes release of corepressor and subsequent binding of coactivators.
In the absence of ligand such as androgen, glucocorticoid, progestin, and mineralocorticoid, the SHR maintains a cytosolic inactive state by association with heat shock proteins and/or other proteins such as corepressors.
The MYND domain is located between the two halves of the SET domain and similar domains have been identified in a number of proteins that function as transcriptional repressors, including the ETO protein that is fused to the AML-1 transcription factor in the t(8;21) translocation in acute myeloid leukemias [ 39 ] . The MYND contains two zinc finger motifs and is a protein-protein interaction interface responsible for the recruitment of corepressors [ 39 40 41 ] .
Hopefully some of the new motifs discovered by Gibbs sampling are real; perhaps they are binding sites for corepressors.
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