Words similar to corepressors

Example sentences for: corepressors

How can you use “corepressors” in a sentence? Here are some example sentences to help you improve your vocabulary:

The MYND domain is located between the two halves of the SET domain and similar domains have been identified in a number of proteins that function as transcriptional repressors, including the ETO protein that is fused to the AML-1 transcription factor in the t(8;21) translocation in acute myeloid leukemias [ 39 ] . The MYND contains two zinc finger motifs and is a protein-protein interaction interface responsible for the recruitment of corepressors [ 39 40 41 ] .
Other known NR corepressors include RIP140 [ 10 ] , Hairless [ 11 ] , short heterodimer partner (SHP) [ 12 ] and DAX [ 13 ] , and receptor specific corepressors such as the estrogen receptor (ER) interacting proteins REA and HET-SAFB [ 14 15 ] .
Thus, the ERs show completely opposite ligand preferences of interaction with corepressors.
In the absence of cognate hormone, several nuclear receptors actively repress transcription of target genes via interactions with the nuclear receptor corepressors SMRT and NCoR.
Generally, NR transcriptional activity is dictated by the balance between coactivator and corepressor recruitment, and one of the most important factors that influences this balance is the absence or presence of agonist ligands (reviewed in [ 4 ] ). Unliganded NRs such as thyroid (TRs) and retinoid receptors (RARs) bind corepressors, and ligand promotes release of corepressor and subsequent binding of coactivators.