Words similar to corepressors
Example sentences for: corepressors
How can you use “corepressors” in a sentence? Here are some example sentences to help you improve your vocabulary:
The MYND domain is located between the two halves of the SET domain and similar domains have been identified in a number of proteins that function as transcriptional repressors, including the ETO protein that is fused to the AML-1 transcription factor in the t(8;21) translocation in acute myeloid leukemias [ 39 ] . The MYND contains two zinc finger motifs and is a protein-protein interaction interface responsible for the recruitment of corepressors [ 39 40 41 ] .
RAR/RXR binding to nuclear receptor corepressors such as NCoR and SMRT in the absence of ligand inhibits activation of RA responsive genes [ 3 4 ] . Ligand binding displaces the repressors and recruits coactivator proteins such as CBP which have histone acetyltransferase activity [ 5 ] . Histone acetylation allows for chromatin unwinding and transcriptional initiation of target gene expression [ 6 ] .
Generally, NR transcriptional activity is dictated by the balance between coactivator and corepressor recruitment, and one of the most important factors that influences this balance is the absence or presence of agonist ligands (reviewed in [ 4 ] ). Unliganded NRs such as thyroid (TRs) and retinoid receptors (RARs) bind corepressors, and ligand promotes release of corepressor and subsequent binding of coactivators.
To investigate ERβ interactions with corepressors, we examined the interactions of full length ERβ (amino acids 1-530) with bacterially expressed C-terminal NR interacting domain of N-CoR (amino acids 1944-2453) in vitro (Fig.
While the ER isoforms have contrasting effects on AP-1 activity in the presence of estrogens, ERα truncations that lack the NTD and ERβ both enhance AP-1 activity in the presence of SERMs [ 30 31 ] . Mutational analysis of ERα action at AP-1 sites suggests these effects may be related to N-CoR binding [ 39 ] , and we have proposed that SERM action at AP-1 sites may therefore involve contacts with corepressors [ 31 51 ] . The fact that ERα and ERβ show completely different ligand preferences of interaction with N-CoR suggests that the target for SERM activation at AP-1 sites may not be N-CoR in both cases.
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