Words similar to corepressors
Example sentences for: corepressors
How can you use “corepressors” in a sentence? Here are some example sentences to help you improve your vocabulary:
This is consistent with the notion that corepressors restrict the activity of agonist-bound ERβ-LBD.
The fact that the mode of ERβ interaction with N-CoR resembles that of NRs with coactivators [ 4 ] , or with corepressors that modulate the activity of liganded NR complexes, such as RIP140 [ 10 ] , raises the possibility that ERβ may be able to recruit N-CoR and SMRT to estrogen-regulated promoters in response to agonists and that the balance of overall ERβ activity in the presence of estrogens may be regulated by competition between p160s and corepressors for the same ERβ AF-2 surface.
While the ER isoforms have contrasting effects on AP-1 activity in the presence of estrogens, ERα truncations that lack the NTD and ERβ both enhance AP-1 activity in the presence of SERMs [ 30 31 ] . Mutational analysis of ERα action at AP-1 sites suggests these effects may be related to N-CoR binding [ 39 ] , and we have proposed that SERM action at AP-1 sites may therefore involve contacts with corepressors [ 31 51 ] . The fact that ERα and ERβ show completely different ligand preferences of interaction with N-CoR suggests that the target for SERM activation at AP-1 sites may not be N-CoR in both cases.
In the absence of ligand such as androgen, glucocorticoid, progestin, and mineralocorticoid, the SHR maintains a cytosolic inactive state by association with heat shock proteins and/or other proteins such as corepressors.
RIP140, Hairless and DAX possess NR boxes that interact with AF-2 [ 11 13 19 ] and these corepressors act as negative regulators of the activity of the liganded NR.
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