Words similar to corepressors
Example sentences for: corepressors
How can you use “corepressors” in a sentence? Here are some example sentences to help you improve your vocabulary:
Since ERβ bound N-CoR and SMRT in the presence of estrogens, we investigated the possible involvement of corepressors in the actions of agonist-bound ERβ in vivo . To perform this experiment, we examined the effect of the HDAC inhibitor trichostatin A (TSA) on ERβ activity in transiently transfected HeLa cells.
In the absence of ligand such as androgen, glucocorticoid, progestin, and mineralocorticoid, the SHR maintains a cytosolic inactive state by association with heat shock proteins and/or other proteins such as corepressors.
The fact that the mode of ERβ interaction with N-CoR resembles that of NRs with coactivators [ 4 ] , or with corepressors that modulate the activity of liganded NR complexes, such as RIP140 [ 10 ] , raises the possibility that ERβ may be able to recruit N-CoR and SMRT to estrogen-regulated promoters in response to agonists and that the balance of overall ERβ activity in the presence of estrogens may be regulated by competition between p160s and corepressors for the same ERβ AF-2 surface.
RAR/RXR binding to nuclear receptor corepressors such as NCoR and SMRT in the absence of ligand inhibits activation of RA responsive genes [ 3 4 ] . Ligand binding displaces the repressors and recruits coactivator proteins such as CBP which have histone acetyltransferase activity [ 5 ] . Histone acetylation allows for chromatin unwinding and transcriptional initiation of target gene expression [ 6 ] .
Other known NR corepressors include RIP140 [ 10 ] , Hairless [ 11 ] , short heterodimer partner (SHP) [ 12 ] and DAX [ 13 ] , and receptor specific corepressors such as the estrogen receptor (ER) interacting proteins REA and HET-SAFB [ 14 15 ] .
Loading...