Words similar to corepressors
Example sentences for: corepressors
How can you use “corepressors” in a sentence? Here are some example sentences to help you improve your vocabulary:
In the absence of ligand such as androgen, glucocorticoid, progestin, and mineralocorticoid, the SHR maintains a cytosolic inactive state by association with heat shock proteins and/or other proteins such as corepressors.
Other known NR corepressors include RIP140 [ 10 ] , Hairless [ 11 ] , short heterodimer partner (SHP) [ 12 ] and DAX [ 13 ] , and receptor specific corepressors such as the estrogen receptor (ER) interacting proteins REA and HET-SAFB [ 14 15 ] .
Other NR coactivators include TRAP220 [ 7 ] , which is part of a larger complex (TRAP/DRIP/SMCC/mediator) that contacts the basal transcription machinery and PGC-1 [ 8 ] , a cold inducible coactivator that binds CBP and SRC-1 and proteins involved in RNA processing [ 9 ] . NR corepressors include NR corepressor (N-CoR) and silencing mediator of retinoid and thyroid responsive transcription (SMRT) [ 4 ] . Both N-CoR and SMRT repress transcription, at least in part, by binding to histone de-acetylases (HDACs) either directly or indirectly through other corepressor complex components.
Hopefully some of the new motifs discovered by Gibbs sampling are real; perhaps they are binding sites for corepressors.
The fact that the mode of ERβ interaction with N-CoR resembles that of NRs with coactivators [ 4 ] , or with corepressors that modulate the activity of liganded NR complexes, such as RIP140 [ 10 ] , raises the possibility that ERβ may be able to recruit N-CoR and SMRT to estrogen-regulated promoters in response to agonists and that the balance of overall ERβ activity in the presence of estrogens may be regulated by competition between p160s and corepressors for the same ERβ AF-2 surface.
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