Words similar to corepressor
Example sentences for: corepressor
How can you use “corepressor” in a sentence? Here are some example sentences to help you improve your vocabulary:
NRs generally interact with the corepressors N-CoR and SMRT either in the absence of ligand, or in the presence of receptor antagonists, and agonists promote corepressor release [ 4 ] . In this study, we demonstrated that ERβ binds to N-CoR in the presence of ER agonists such as estradiol and DES and the phytoestrogens genistein and coumestrol, but not in the presence of SERMs.
Other NR coactivators include TRAP220 [ 7 ] , which is part of a larger complex (TRAP/DRIP/SMCC/mediator) that contacts the basal transcription machinery and PGC-1 [ 8 ] , a cold inducible coactivator that binds CBP and SRC-1 and proteins involved in RNA processing [ 9 ] . NR corepressors include NR corepressor (N-CoR) and silencing mediator of retinoid and thyroid responsive transcription (SMRT) [ 4 ] . Both N-CoR and SMRT repress transcription, at least in part, by binding to histone de-acetylases (HDACs) either directly or indirectly through other corepressor complex components.
Similar agonist-dependent interactions could be observed between ERβ and the alternate NR corepressor SMRT in vitro (Fig.
Thus, corepressor complex HDACs must play an unspecified role in restricting the transcriptional activity of both ERβ and, in particular, the ERβ-LBD.
The nuclear receptor (NR) family comprises 48 structurally related transcription factors, many of which require their cognate ligand for activity [ 1 2 3 ] . The NRs regulate transcription by binding to response elements in the promoters of target genes and acting as scaffolds for the assembly of large coactivator and corepressor complexes [ 4 ] . NR coactivators include the p160s (including GRIP1/TIF-2, SRC-1 and AIB1/ACTR/pCIP).
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