Words similar to corepressor

Example sentences for: corepressor

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Generally, NR transcriptional activity is dictated by the balance between coactivator and corepressor recruitment, and one of the most important factors that influences this balance is the absence or presence of agonist ligands (reviewed in [ 4 ] ). Unliganded NRs such as thyroid (TRs) and retinoid receptors (RARs) bind corepressors, and ligand promotes release of corepressor and subsequent binding of coactivators.
In other cases, however, the balance of coactivator and corepressor recruitment is regulated by direct competition for the AF-2 surface, rather than ligand-dependent coregulator exchange.
Consistent with this notion, the apparent weak transcriptional activity of the ERβ LBD is a consequence of corepressor HDAC activity at some level (Fig.
The finding that estrogens suppress N-CoR binding to ERα [ 39 ] , but promote N-CoR binding to ERβ represents the first demonstration of a corepressor that shows completely distinct modes of hormone-dependent interaction with the ER isoforms.
Similar agonist-dependent interactions could be observed between ERβ and the alternate NR corepressor SMRT in vitro (Fig.