Words similar to corepressor

Example sentences for: corepressor

How can you use “corepressor” in a sentence? Here are some example sentences to help you improve your vocabulary:

N-CoR Nuclear receptor corepressor
The finding that estrogens suppress N-CoR binding to ERα [ 39 ] , but promote N-CoR binding to ERβ represents the first demonstration of a corepressor that shows completely distinct modes of hormone-dependent interaction with the ER isoforms.
NRs generally interact with the corepressors N-CoR and SMRT either in the absence of ligand, or in the presence of receptor antagonists, and agonists promote corepressor release [ 4 ] . In this study, we demonstrated that ERβ binds to N-CoR in the presence of ER agonists such as estradiol and DES and the phytoestrogens genistein and coumestrol, but not in the presence of SERMs.
The nuclear receptor (NR) family comprises 48 structurally related transcription factors, many of which require their cognate ligand for activity [ 1 2 3 ] . The NRs regulate transcription by binding to response elements in the promoters of target genes and acting as scaffolds for the assembly of large coactivator and corepressor complexes [ 4 ] . NR coactivators include the p160s (including GRIP1/TIF-2, SRC-1 and AIB1/ACTR/pCIP).
Consistent with this notion, the apparent weak transcriptional activity of the ERβ LBD is a consequence of corepressor HDAC activity at some level (Fig.