Words similar to coreceptors
Example sentences for: coreceptors
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Earlier studies describing the underlying molecular mechanisms involved in the HIV-1 inhibitory effect of the candidate microbicide CAP indicated that this compound remains bound to HIV-1, impairing virus infectivity by blockade of binding sites for cellular coreceptors CXCR4 and CCR5 [ 8 ] . Results reported here further extend these findings and show that: 1) there is synergism between sCD4 and CAP for inhibition of virus infectivity; 2) CAP binding to HIV-1 leads to conformational changes in viral envelope glycoproteins resulting in the expression of functionally inert six-helix bundle structures.
Pretreatment with CAP impairs gp120 binding to coreceptors
These results indicate that treated HIV-1 particles, utilizing either CXCR4 or CCR5 as coreceptors, retain CAP on their surface and suggest that this is responsible for the altered properties and impaired infectivity of the treated viruses.
Thus, CAP would be expected to affect one or more steps required for HIV-1 entry into cells, i.e. binding to cellular CD4, to the major HIV-1 coreceptors CXCR4 or CCR5 for X4 and R5 viruses [ 6 ] , respectively, and fusion with cell membranes [ 7 8 9 10 11 12 13 14 15 ] . Results presented here show that CAP pretreated HIV-1 has a reduced capacity to bind to the coreceptors leading to impaired virus infectivity.
Thus, it would be expected that CAP would not inhibit the attachment of HIV-1 to target cells and would block only subsequent steps obligatory for HIV-1 infection initiated by engagement of CXCR4 and CCR5 coreceptors, respectively.
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