Words similar to coreceptor

Example sentences for: coreceptor

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Soluble CAP at neutral pH was shown to bind strongly to the coreceptor binding sites on gp120 of both X4 and R5 viruses [ 36 ] and to elicit the formation of gp41 six-helix bundles, the hallmark of irreversible virus inactivation [ 37 ] . Thus, HIV-1 exposed to CAP at sufficient concentrations is rendered noninfectious, and continued presence of CAP is not required to maintain lack of infectivity.
Earlier studies [ 36 37 ] . indicated that soluble CAP at neutral pH binds to the CXCR4 and CCR5 coreceptor binding sites on HIV-1 IIIB and BaL, respectively, and induced the formation of "dead-end" gp41 six-helix bundles.
To further support this conclusion, the binding of labeled gp120-CD4 complexes to coreceptor [ 11 12 33 ] expressing cells was studied.
The hypothesis that engagement of coreceptor binding sites on gp120 by CAP leads to the expression of gp41 six-helix bundle structures is supported by the finding that a tyrosine sulfated S-peptide, but not the non-sulfated peptide, from the N-terminus of CCR5 [ 25 56 57 ] has an effect similar to that of CAP (Fig.
Data reported so far suggest that the lethal hit to HIV-1 caused by CAP treatment involves the coreceptor binding site on gp120.