Example sentences for: coreceptor

How can you use “coreceptor” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Consistent with our microarray results on CCR5 up-regulation, experiments performed in peripheral blood mononuclear cells (PBMCs) with soluble Tat has shown selective entry and replication of CCR5 virus into cells [ 27 28 ] . Up-regulation of HIV-1 coreceptor by Tat has also been reported, where a synthetic Tat protein that was immobilized on a solid substrate, up-regulated the surface expression of the chemokine receptors in purified populations of primary resting CD4+ T cells.

  • Since CAP blocks coreceptor binding sites on gp120 [ 8 ] it was of interest to determine whether this blockade would lead to conformational changes in HIV-1 gp41, similar to those elicited by CD4 or coreceptor binding to gp120.

  • Earlier studies [ 8 ] indicated that CAP treated HIV-1 particles have their coreceptor, i.e.

  • In parallel to using more realistic, lower challenge doses, other crucial parameters of the experimental infection process, such as the route of transmission and the coreceptor usage of the challenge virus, should also be chosen to be as realistic as possible.

  • In agreement with this finding, CAP inhibited infection by both X4 and R5 viruses in in vitro models for vaginal HIV-1 infection [ 45 50 ] . Sites on the HIV-1 envelope other than the coreceptor binding domains may possibly be also involved in interactions with CAP, contributing to inhibition of virus infection.


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