Words similar to coreceptor

Example sentences for: coreceptor

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Soluble CAP at neutral pH was shown to bind strongly to the coreceptor binding sites on gp120 of both X4 and R5 viruses [ 36 ] and to elicit the formation of gp41 six-helix bundles, the hallmark of irreversible virus inactivation [ 37 ] . Thus, HIV-1 exposed to CAP at sufficient concentrations is rendered noninfectious, and continued presence of CAP is not required to maintain lack of infectivity.
These more realistic choices of the route of infection and coreceptor usage will permit the assessment of the efficacy of the preventive intervention in a setting that more accurately reflects HIV exposures of humans, and will enable us to carefully investigate the processes that give rise to infection.
1), in agreement with recent observations [ 44 45 ] . Virus inactivation can be attributed to strong binding of CAP to HIV-1, preventing the access to virus particles predominantly of antibodies against the gp120 V3 loop, known to be involved in coreceptor binding and specificity [ 15 46 47 48 49 ] , and to epitopes located adjacent to the V3 loop (Fig.
To further support this conclusion, the binding of labeled gp120-CD4 complexes to coreceptor [ 11 12 33 ] expressing cells was studied.
For this reason it was of interest to study the virucidal activity of anionic polymeric microbicide candidates against both X4 (using CXCR4 as coreceptor) and R5 (using CCR5 as coreceptor) viruses, the latter being most frequently transmitted sexually [ 39 ] .