Example sentences for: coreceptor

How can you use “coreceptor” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Indeed, CAP binding to HIV-1 resulted in blockade of sites involved in coreceptor binding (Fig.

  • Earlier studies [ 8 ] indicated that CAP treated HIV-1 particles have their coreceptor, i.e.

  • In parallel to using more realistic, lower challenge doses, other crucial parameters of the experimental infection process, such as the route of transmission and the coreceptor usage of the challenge virus, should also be chosen to be as realistic as possible.

  • In agreement with this finding, CAP inhibited infection by both X4 and R5 viruses in in vitro models for vaginal HIV-1 infection [ 45 50 ] . Sites on the HIV-1 envelope other than the coreceptor binding domains may possibly be also involved in interactions with CAP, contributing to inhibition of virus infection.

  • The occupancy of CD4 and coreceptor binding sites by their respective ligands elicits downstream conformational changes in the envelope glycoprotein gp41, rendering it competent for fusion between virus and target cell membranes [ 18 19 40 41 42 43 ] . Shedding of gp120 from virus particles is not required for subsequent membrane fusion events [ 44 ] . The induction of gp41 six-helix bundles, detectable by mAb NC-1, by CAP in the absence of gp120 shedding is consistent with this conclusion.


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