Words similar to coreceptor
Example sentences for: coreceptor
How can you use “coreceptor” in a sentence? Here are some example sentences to help you improve your vocabulary:
The occupancy of CD4 and coreceptor binding sites by their respective ligands elicits downstream conformational changes in the envelope glycoprotein gp41, rendering it competent for fusion between virus and target cell membranes [ 18 19 40 41 42 43 ] . Shedding of gp120 from virus particles is not required for subsequent membrane fusion events [ 44 ] . The induction of gp41 six-helix bundles, detectable by mAb NC-1, by CAP in the absence of gp120 shedding is consistent with this conclusion.
The hypothesis that engagement of coreceptor binding sites on gp120 by CAP leads to the expression of gp41 six-helix bundle structures is supported by the finding that a tyrosine sulfated S-peptide, but not the non-sulfated peptide, from the N-terminus of CCR5 [ 25 56 57 ] has an effect similar to that of CAP (Fig.
On the other hand, gp120-sCD4 complexes containing CAP treated gp120 bound to coreceptor expressing cells to a much lesser extent than similar complexes containing untreated gp120 (Fig.
For this reason it was of interest to study the virucidal activity of anionic polymeric microbicide candidates against both X4 (using CXCR4 as coreceptor) and R5 (using CCR5 as coreceptor) viruses, the latter being most frequently transmitted sexually [ 39 ] .
Engagement of the gp120 coreceptor binding site with a tyrosine sulfated peptide from the N-terminus of the coreceptor CCR5 [ 25 ] , shown to inhibit infection by CCR5-dependent, but not CXCR4-dependent, HIV-1 isolates, was sufficient to increase the expression of the gp41 six-helix bundles in HIV-1 BaL virus particles (Fig.
Loading...