Words similar to constitutive

Example sentences for: constitutive

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The constitutive activation of Stat3 found in prostate cancer [ 27 43 ] could be an initial step in the clonal selection of malignant cells affecting not only Stat3-regulated genes but also AR, as part of the transcription complex recruited in response to activated AR.
It is possible that exogenous or autocrine IL-6 is not required for constitutive STAT3 activation in NRP-154 cells.
IL-6 given exogenously, since LNCaP cells do not produce IL-6, resulted in increased growth of the cells concomitant with activation of STAT3 [ 36 ] . LNCaP cells transfected with a plasmid conferring constitutive IL-6 expression demonstrated increased growth, relative to untransfected or sham-transfected cells [ 36 ] . However, other investigators have observed that IL-6 treatment of LNCaP cells reulted in terminal differentiation and inhibition of growth, associated with STAT3 activation [ 17 37 38 ] . The molecular basis for the apparent contradiction is unknown at this time.
Likewise, no significant difference in apoptosis was observed between clones with constitutive Syk activity and controls (Figure 7B).
However, no impact on cell growth in culture was found in clones with high constitutive Syk activity, nor was the growth suppressive effect of anti-IgM treatment enhanced (Figure 7A).