Words similar to constitutive

Example sentences for: constitutive

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First, expression of the (K395A/3F)Syk molecule in BCL 1 .3B3 results in constitutive activation of endogenous Syk.
The enzyme exhibits a high constitutive activity in vitro, but it too can be activated by ARF (reviewed in [ 7 ] ), and by phorbol esters, in intact cells [ 6 9 ] . Several reports have suggested that PLD2 is mainly localized to the plasma membrane [ 6 10 ] , possibly in lipid rafts and caveolar membrane microdomains [ 11 12 ] . Most studies on the physiological functions of PLDs have focused on the product PA, a second messenger involved in mitosis, cellular morphological changes and vesicular trafficking (reviewed in [ 7 13 ] ). However, the downstream events that occur as a consequence of PLD-generated PA production, and the identity of target proteins that are directly regulated by PA remains to be determined.
However, no impact on cell growth in culture was found in clones with high constitutive Syk activity, nor was the growth suppressive effect of anti-IgM treatment enhanced (Figure 7A).
The lower levels of Smad1, Smad4, Az and SNIP1 in lane 1 compared with those in lane 10 suggest that the leaky signaling by the overexpressed ALK3, which we have demonstrated recently [ 39 ] , caused a constitutive reduction of Smad4, Az and SNIP1 level that is dependent upon the activation of Smad1.
When the (K395A/3F)Syk mutant was co-expressed with endogenous Syk in BCL 1 .3B3 cells, a constitutive Syk activation phenotype was observed.