Words similar to conjoined
Example sentences for: conjoined
How can you use “conjoined” in a sentence? Here are some example sentences to help you improve your vocabulary:
The effector specificity could be rationally changed by changing the specificity of the conjoined aptamer: when a mutation was introduced into the anti-theophylline aptamer that led to discrimination against theophylline and in favor of 3-methylxanthine (that also differed from theophylline by a single methyl group), the aptamer became solely responsive to 3-methylxanthine in vivo . Group I aptazymes may have a number of important biotechnology applications, including use as in vivo , real-time reporters and as regulatable gene therapeutics.
This antiserum reacts with the CT molecule, whether it is in the free, amidated, 32-amino acid mature form, or within its precursor propeptides [ie procalcitonin, the conjoined calcitonin:calcitonin carboxypeptide-I (CT:CCP-1), or the free immature, unamidated CT].
As always in any collection of wordplays, many— most—are terrible or toothless (e.g., Tuning Fork , which lacks the desirable distance between the two items suddenly conjoined).
Using an antiserum to CT which recognizes the free mature CT, the immature CT within the ProCT molecule, and the conjoined CT:CCP-1 peptide, we have demonstrated that levels of serum total iCT are also elevated in the septic hamster.
For example, Herschlag and co-workers have previously shown that a nucleobase could complement an abasic site within the hammerhead ribozyme, restoring cleavage activity [ 1 ] . Similarly, Porta and Lizardi engineered a hammerhead ribozyme that assumed an inactive secondary structure; upon the addition of an oligonucleotide that disrupted the engineered secondary structure, the ribozyme was activated [ 2 ] . More recently, it has previously been shown that many selected nucleic acid binding species (aptamers) undergo conformational changes upon ligand binding [ 3 4 5 6 ] In addition, when aptamers are conjoined to ribozymes, the ligand-induced conformational changes in the aptamers frequently modulate the structures and hence the activities of the ribozymes [ 7 8 9 ] For example, binding of theophylline to the anti-theophylline aptamer [ 10 ] modulates the conformation of residue [ 11 12 ] and the overall stability of the aptamer [ 10 13 ] . Appending the anti-theophylline aptamer to the hammerhead ribozyme allowed cleavage activity to be modulated by 110-fold by theophylline [ 13 ] . Similarly, appending the anti-theophylline aptamer to a small ribozyme ligase (L1) generated an aptazyme that was activated 1,600-fold by saturating theophylline concentrations [ 14 ] .
Loading...