Words similar to conjoined
Example sentences for: conjoined
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The effector specificity could be rationally changed by changing the specificity of the conjoined aptamer: when a mutation was introduced into the anti-theophylline aptamer that led to discrimination against theophylline and in favor of 3-methylxanthine (that also differed from theophylline by a single methyl group), the aptamer became solely responsive to 3-methylxanthine in vivo . Group I aptazymes may have a number of important biotechnology applications, including use as in vivo , real-time reporters and as regulatable gene therapeutics.
For example, Herschlag and co-workers have previously shown that a nucleobase could complement an abasic site within the hammerhead ribozyme, restoring cleavage activity [ 1 ] . Similarly, Porta and Lizardi engineered a hammerhead ribozyme that assumed an inactive secondary structure; upon the addition of an oligonucleotide that disrupted the engineered secondary structure, the ribozyme was activated [ 2 ] . More recently, it has previously been shown that many selected nucleic acid binding species (aptamers) undergo conformational changes upon ligand binding [ 3 4 5 6 ] In addition, when aptamers are conjoined to ribozymes, the ligand-induced conformational changes in the aptamers frequently modulate the structures and hence the activities of the ribozymes [ 7 8 9 ] For example, binding of theophylline to the anti-theophylline aptamer [ 10 ] modulates the conformation of residue [ 11 12 ] and the overall stability of the aptamer [ 10 13 ] . Appending the anti-theophylline aptamer to the hammerhead ribozyme allowed cleavage activity to be modulated by 110-fold by theophylline [ 13 ] . Similarly, appending the anti-theophylline aptamer to a small ribozyme ligase (L1) generated an aptazyme that was activated 1,600-fold by saturating theophylline concentrations [ 14 ] .
This antiserum reacts with the CT molecule, whether it is in the free, amidated, 32-amino acid mature form, or within its precursor propeptides [ie procalcitonin, the conjoined calcitonin:calcitonin carboxypeptide-I (CT:CCP-1), or the free immature, unamidated CT].
As always in any collection of wordplays, many— most—are terrible or toothless (e.g., Tuning Fork , which lacks the desirable distance between the two items suddenly conjoined).
The first is an absorbing, low-budget art movie about conjoined twins, the weaker of whom is dying and mordant, the other torn (so to speak) between loyalty to his brother and a tenuous connection to the external world--embodied in part by a prostitute (Michele Hicks) who looks like Bridget Fonda as Vampira and acts like a slightly less wooden porn star.
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