Example sentences for: coagulation

How can you use “coagulation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • TSP-1 is a homotrimeric multidomain glycoprotein synthesized and secreted by numerous cell types, including platelets, vascular smooth muscle cells and keratinocytes [ 4 ] . Due to its interaction with a wide variety of proteins, TSP-1 has been implicated in a number of biological processes including coagulation, cell adhesion, the modulation of cell-cell and cell-matrix interactions, control of tumor growth and metastasis, and angiogenesis [ 10 ] . Inhibition of tumor cell proliferation has been achieved in vivo by systemic treatment with TSP-1 peptide mimetics [ 11 ] , but a correlation between primary tumor TSP-1 expression and poor prognosis has not been clearly established [ 12 ] . While there are reports that these molecules can originate from tumor cells [ 13 ] , the majority of reports have suggested that the major source of both TSP-1 and OPN is tumor-associated stroma [ 14 ] or infiltrating macrophages and lymphocytes [ 15 ] .

  • For example, because about 80% of strokes are caused by thrombotic occlusion of a blood vessel, genes related to the coagulation system would seem logical candidates for susceptibility to stroke.

  • The EGF domain, which often occurs as multiple tandem repeats, is widely distributed among extracellular proteins involved in adhesion, receptor-ligand interactions, extracellular matrix structure, determination of cell fate, and blood coagulation [ 27 ] . Cell adhesion usually activates PI 3-kinase activity.

  • In particular these studies have shown the overall benefit of physical activity in reducing the risk of developing coronary heart disease, especially due to the reduction of arterial blood pressure levels [ 8 9 10 11 ] , inflammation and coagulation markers [ 7 12 ] . One of the main findings of the present work is the dose-response relationship between physical activity and HDL cholesterol levels, in women.

  • Until recently, the only known hypercoagulable states were several rare genetic disorders of the coagulation cascade (antithrombin III, protein C, and protein S deficiency), which accounted for only a small percentage of all patients with venous thrombosis [ 16].


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