Words similar to coactivators

Example sentences for: coactivators

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[ 18 ] . This constitutively activated Stat3 (a mutant produced by substitution of the cysteine residues within the COOH-terminal loop of the SH2 domain of Stat3) induces cellular transformation and tumor formation in nude mice [ 18 ] . The plasmids to express other coactivators (SRC-1, CBP/p300, TIF2 and PCAF) have been described elsewhere [ 29 30 ] .
In the presence of pon A the ecdysone receptor recruits coactivators that lead to elevated expression.
Generally, NR transcriptional activity is dictated by the balance between coactivator and corepressor recruitment, and one of the most important factors that influences this balance is the absence or presence of agonist ligands (reviewed in [ 4 ] ). Unliganded NRs such as thyroid (TRs) and retinoid receptors (RARs) bind corepressors, and ligand promotes release of corepressor and subsequent binding of coactivators.
In experiments studying synergy of coactivators, the total amount of DNA was kept constant at 4.4 μg per well.
Several possible mechanisms have been suggested to explain this activation of AR, including mutations in the gene encoding AR that alter the specificity for androgens, overexpression of the AR protein itself, cross-talk to other signal transduction pathways, and altered levels or activity of coactivators [ 21 22 23 ] . Several groups including ours have demonstrated a role of activated Stat3 in the proliferation and survival of prostate cancer cells by a mechanism that involves the AR [ 24 25 26 27 28 ] .