Words similar to coactivators

Example sentences for: coactivators

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[ 18 ] . This constitutively activated Stat3 (a mutant produced by substitution of the cysteine residues within the COOH-terminal loop of the SH2 domain of Stat3) induces cellular transformation and tumor formation in nude mice [ 18 ] . The plasmids to express other coactivators (SRC-1, CBP/p300, TIF2 and PCAF) have been described elsewhere [ 29 30 ] .
Moreover, Stat3 has also been directly associated with several coactivators, such as SRC-1 and CBP/p300 [ 9 12 ] . Recruitment of coactivators to nuclear receptors takes place via a common motif in the coactivators containing a core consensus sequence LXXLL (L, leucine; X, any aminoacid) [ 38 ] . Most of the coactivators contain more than one of these motifs, raising the question regarding specificity of these motifs to specific activating domains in the nuclear receptors.
Stat3 is comparable to other coactivators on AR transcriptional activity: SRC-1, CBP/p300, TIF2, P/CAF.
Accessory cells were effectively removed during T cell isolation as shown by the failure of mitogen-induced proliferation in the absence of coactivators.
Here we show that constitutively active Stat3 enhances transcriptional activity of SHRs, AR, GR, PR, and ER, in a comparable extent to the stimulation elicit by other coactivators, and even more, in a synergistic manner to these other coactivators.