Words similar to coactivators

Example sentences for: coactivators

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Recent results suggest that the C-terminal helix 12 of RXR exerts allosteric effects on RAR function [ 6 ] . However, additional studies suggest that corepressor binding to the apo-RAR component of the heterodimer blocks rexinoid induced binding of coactivators to RXR [ 7 ] . These results suggest that the mechanisms that account for the lack of responsiveness of the non-permissive complexes are complex.
We next compared the coactivator activity of Stat3 to that of other known coactivators for AR.
Moreover, TAFs serve as coactivators to a diverse set of activators.
Similarly to nuclear receptors and to other transcription factors, STAT proteins can interact with coactivators to modulate their transcriptional activity [ 9 10 11 12 ] . Other reports have shown direct interactions between several members of the JAK/STAT signaling pathway with SHRs [ 13 14 15 16 ] . Stat3 is one of the seven members of the STAT family of proteins that has been shown to modulate the expression of several genes related to control cell cycle, proliferation and apoptosis, such as Cyclin D1, c-myc, and Bcl-xL, respectively [ 17 ] . Accordingly, alterations in the activity of STAT3 have been associated with cell transformation and cancer progression [ 18 19 20 ] .
3shows, coexpression of active Stat3C simultaneously to SRC-1, CBP/p300, TIF-2 or P/CAF, resulted in a more efficient enhancement of the reporter transcription activity driven by AR as compared with any of the coactivators expressed separately.