Words similar to coactivator
Example sentences for: coactivator
How can you use “coactivator” in a sentence? Here are some example sentences to help you improve your vocabulary:
We studied whether Stat3, a transcription factor itself, could act as a coactivator for AR and for other SHRs.
Indeed, as P-TEFb is a coactivator of potent activators that mediate effects of enhancers and can itself activate transcription when placed on sites distal to promoter elements [15], it might mediate many more signaling events than those of heat shock, ultraviolet light, stress, and hypertrophy.
PGC1-α, a transcriptional coactivator of nuclear receptors important to the regulation of a number of mitochondrial genes involved in oxidative metabolism, directly interacts with MEF2 to synergistically activate selective ST muscle genes and also serves as a target for calcineurin signaling (Lin et al.
Stat3 also contains in its N-terminus one of this motifs ( 221LAGLL 225) [ 39 ] . Moreover, Stat3 also presents a Ser at -2 position of the LXXLL sequence, which in the case of the coactivator TRBP defines selectivity for nuclear receptors [ 40 ] . Phosphorylation of Stat3 has been reported to occur only in 705Tyr and in 727Ser, allowing dimerization and full transactivating activity [ 41 ] . Whether this 219Ser next to the LXXLL motif is involved in the coactivator activity of Stat3, and the interaction of Stat3 with other coactivators only takes place in the context of Stat3 transcription factor activity or also can be part of the general mechanism of the transcription complex formation requires further studies.
For example, KIF17a, a member of the N-4 subgroup that is predominantly expressed in germ cells, was recently shown to possess transcriptional regulatory properties by controlling access of the transcriptional activator protein CREM to a coactivator, ACT [ 37 ] . Clearly, functional analysis of the KIF27 polypeptide will be needed to determine the subcellular location of this protein to determine whether it may add to the growing number of kinesins that function in the nucleus.
Loading...