Example sentences for: coactivator

How can you use “coactivator” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Taken together, Stat3 enhances four different SHRs transcriptional activity in the presence of their corresponding ligand, suggesting that active Stat3 acts as a coactivator for nuclear receptors.

  • Remarkably, however, coactivator binding is decreased in the presence of both of the activating ligands.

  • For example, KIF17a, a member of the N-4 subgroup that is predominantly expressed in germ cells, was recently shown to possess transcriptional regulatory properties by controlling access of the transcriptional activator protein CREM to a coactivator, ACT [ 37 ] . Clearly, functional analysis of the KIF27 polypeptide will be needed to determine the subcellular location of this protein to determine whether it may add to the growing number of kinesins that function in the nucleus.

  • Here, we describe the effect of coactivator proteins SRC-1 (Acc# AJ000882, U90661, Table 1) and p300 (Acc# U01877, Table 3), and their relation to differentiation genes such as retinoic acid receptor (RAR/PML, Acc#: X06614, Table 1), and Leptin receptor variant (Acc#: U66496, Table 1); all of which are down-regulated in Tat expressing cells (Figure 5).

  • Sp1 and CREB interact with distinct glutamine-rich domains of TAF II 135 and TAF II 135 acts as a coactivator in vitro for these activators.


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