Words similar to cholestatic
Example sentences for: cholestatic
How can you use “cholestatic” in a sentence? Here are some example sentences to help you improve your vocabulary:
Our patient had severe cholestatic hepatitis with coagulopathy.
However, the mechanisms of liver injury in cholestatic diseases in infants remain unclear.
hepatomegaly) to well proven cases of liver disease [ 1 2 3 4 5 6 7 28 ] . Denko in 1960 reported that 12% of patients with SS had hepatosplenomegaly [ 29 ] . Other studies done in the 1960's also confirmed hepatomegaly in 18-20% of patients with SS [ 30 31 ] . In 1970, Whaley reported liver disease in 6% of patients with SS and mentioned an association with anti-mitochondrial antibodies [ 2 ] . In 1986, Tsianos and co-workers described 22 SS patients with gastrointestinal complications, called from a large cohort; only two patients had liver disease, each with chronic active hepatitis [ 4 ] . Other studies have reported variable prevalence [ 3 28 ] and different histopathological findings in liver biopsies ranging from cholestatic liver damage (stage I primary biliary cirrhosis) to chronic active hepatitis due to hepatitis C virus.
Sulfasalazine (SSZ) is a widely used and highly effective anti-inflammatory agent in the treatment of Crohn's disease and ulcerative colitis [ 1 2 3 ] . SSZ is also being used with increasing frequency in the treatment of various rheumatolgical disorders [ 4 5 6 7 ] . SSZ is preferred over other agents such as gold and penicillamine in rheumatology patients due to its more favorable side effect profile [ 8 9 10 ] . Nonetheless, rash, fever, and dyspepsia occur in 3% to 20% of treated patients [ 7 11 12 ] . These reactions are usually dose dependent and improve with dose reduction or discontinuation [ 7 12 ] . However, more serious but less common side effects have also been reported [ 13 14 15 16 17 18 19 ] . We now report a severe systemic reaction to SSZ in a 21-year-old female with rheumatoid arthritis characterized by granulomatous infiltration of the bone marrow, colon and small bowel as well as cholestatic hepatitis and seizures.
Animal studies using models of surgically induced extrahepatic biliary obstruction have also shown that lipid peroxidation products - specifically, malondialdehyde (MDA) - are increased in the cholestatic liver [ 8, 9].
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