Words similar to cholestatic
Example sentences for: cholestatic
How can you use “cholestatic” in a sentence? Here are some example sentences to help you improve your vocabulary:
Some studies have suggested that excessive amino acids, hepatotoxic bile acids, bacterial overgrowth, sepsis, micronutrient deficiency, and TPN contaminants all contribute to cholestatic liver injury [ 4, 5, 6].
hepatomegaly) to well proven cases of liver disease [ 1 2 3 4 5 6 7 28 ] . Denko in 1960 reported that 12% of patients with SS had hepatosplenomegaly [ 29 ] . Other studies done in the 1960's also confirmed hepatomegaly in 18-20% of patients with SS [ 30 31 ] . In 1970, Whaley reported liver disease in 6% of patients with SS and mentioned an association with anti-mitochondrial antibodies [ 2 ] . In 1986, Tsianos and co-workers described 22 SS patients with gastrointestinal complications, called from a large cohort; only two patients had liver disease, each with chronic active hepatitis [ 4 ] . Other studies have reported variable prevalence [ 3 28 ] and different histopathological findings in liver biopsies ranging from cholestatic liver damage (stage I primary biliary cirrhosis) to chronic active hepatitis due to hepatitis C virus.
To date, the genes that have been shown to be responsive to regulation by FXR encode proteins involved in the biosynthesis and transport of bile acids [ 13 ] . Bile acids have been shown to modulate a variety of other cellular functions, such as secretion of lipoproteins from hepatocytes [ 14 15 ] and translocation of bile acid transporters to the hepatocyte canalicular membrane [ 16 ] . In McNtcp cells, which are liver-derived cells engineered to transport bile acids actively [ 17 ] , taurine-conjugated bile acids induce the formation of intracellular vesicles that resembles structures observed in cholestatic liver cells without apparent cellular cytotoxicity [ 1 18 ] . In contrast, glycine-conjugated bile acids promote apoptosis in these cells [ 19 ] . Thus, different classes of conjugated bile acids stimulate distinctive responses in McNtcp cells.
Our patient had severe cholestatic hepatitis with coagulopathy.
Animal studies using models of surgically induced extrahepatic biliary obstruction have also shown that lipid peroxidation products - specifically, malondialdehyde (MDA) - are increased in the cholestatic liver [ 8, 9].
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