Words similar to chaperones
Example sentences for: chaperones
How can you use “chaperones” in a sentence? Here are some example sentences to help you improve your vocabulary:
indicating a possible role for HSP70 in fertilization [ 41 ] ). An egg-surface sperm receptor, identified on sea urchin oocytes, bears a sperm-binding domain with sequence similarity to HSP70 and its recombinant protein binds sperm and inhibits fertilization in vitro [ 42 ] . Among the other molecular chaperones described here, calreticulin has been found in oocytes from a number of species [ 43 ] . Interestingly, Munoz-Gotera et al.
The first, the ER overload response, triggers the activation of the transcription factor NFkB and the subsequent upregulation of inflammatory proteins [ 13 ] . The second, the unfolded protein response (UPR) induces three divergent cellular events: (i) the activation of transcription factor ATF6 leading to the upregulation of ER chaperones such as protein disulfide isomerase, (ii) upregulation of the pro-apoptotic transcription factor GADD153 and (iii) suppression of protein synthesis via phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) by pancreatic eIF2α kinase (PEK/PERK, [ 11 12 ] ). Upregulation of the ER chaperones, GADD153 and PERK in response to a toxic insult would constitute direct evidence of an ER stress response.
Constitutive expression of a number of HSPs and molecular chaperones has been characterized in immature oocytes and mature mouse eggs [ 38 39 40 ] , though none as yet have been localized to the oolemma.
They can act as anti-oxidants (to prevent damage from oxygen radicals), as chaperones (to prevent misfolded proteins from forming aggregates), as antimicrobials (to protect against bacteria and fungi), and as metabolic agents.
Molecular chaperones bind to nascent proteins in the endoplasmic reticulum (ER), promote proper protein folding, and prevent the aggregation of nonnative and misfolded proteins.
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