Example sentences for: chaperones

How can you use “chaperones” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • ER function is critical if protein synthesis and folding is to successfully occur in eukaryotic cells [ 11 12 ] . ER stress, induced by cellular events as diverse as disrupted calcium homeostasis, elevated levels of reactive oxygen species and viral infection, leads to accumulation of dysfunctional ER chaperones and misfolded proteins [ 11 ] . Cells respond by one or both of two conserved stress response pathways.

  • Compromised ER function (induced by numerous stressors including depletion of ER calcium stores) may lead to the accumulation of unfolded proteins in the ER [ 11 ] . These events may trigger the UPR, in which the transcription of genes encoding ER-resident chaperones is upregulated.

  • Of the spots submitted, a subset matched known chaperones/HSP proteins; these are HSP70, HSP90α, GRP78, GRP94, Calreticulin, Calnexin, PDI, and ORP150, as indicated by labelled arrows in Fig.

  • They can act as anti-oxidants (to prevent damage from oxygen radicals), as chaperones (to prevent misfolded proteins from forming aggregates), as antimicrobials (to protect against bacteria and fungi), and as metabolic agents.

  • We report here the preliminary identification of nine highly abundant HSPs and related chaperones in the mature mouse egg that also appear to be surface labelled.


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