Words similar to chaperones
Example sentences for: chaperones
How can you use “chaperones” in a sentence? Here are some example sentences to help you improve your vocabulary:
The Rat Genome U34 array was found to contain probe-sets representing the ER chaperones glucose-regulated protein (GRP) 78, protein disulfide isomerase, GRP94, calreticulin and endoplasmic reticulum protein 29 (EPR29), GADD153 and PERK.
Molecular chaperones bind to nascent proteins in the endoplasmic reticulum (ER), promote proper protein folding, and prevent the aggregation of nonnative and misfolded proteins.
When the experiment clustering was performed on the basis of genes encoding protein-folding chaperones (the top 10 genes in cluster 11), a striking similarity between the effects of diamide and heat shock was observed (Figure 8b).
Another preliminary finding of this study is that several molecular chaperones appear to be localized to the egg surface.
The first, the ER overload response, triggers the activation of the transcription factor NFkB and the subsequent upregulation of inflammatory proteins [ 13 ] . The second, the unfolded protein response (UPR) induces three divergent cellular events: (i) the activation of transcription factor ATF6 leading to the upregulation of ER chaperones such as protein disulfide isomerase, (ii) upregulation of the pro-apoptotic transcription factor GADD153 and (iii) suppression of protein synthesis via phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) by pancreatic eIF2α kinase (PEK/PERK, [ 11 12 ] ). Upregulation of the ER chaperones, GADD153 and PERK in response to a toxic insult would constitute direct evidence of an ER stress response.
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