Words similar to chaperon
Example sentences for: chaperon
How can you use “chaperon” in a sentence? Here are some example sentences to help you improve your vocabulary:
He is brought by his chauffeur, who acts as chaperon but they decide that he will be de trop and he takes French leave.
However, dramatic reduction of copper in SOD1 by knocking out the copper chaperon for SOD1 (CCS), or by mutating the copper chelating residues, did not affect ALS progression in vivo [ 36 48 ] . Therefore, the role of copper-mediated oxidative damage remains unclear [ 49 50 ] .
A small protein Ump1 associates with the premature proteasome complexes and is shown to be involved in assisting the maturation of 20S proteasome, possibly by interacting with the β rings of half proteasomes [ 46 ] . Upon the maturation of the 20S proteasome, Ump1 is trapped inside the proteasome and is degraded by proteasome [ 46 ] . The HSP70 like chaperon protein Hsc73 also associates with the 16S proteasome precursor complexes [ 35 36 ] . The exact role of Hsc73 in 16S precursor proteasome complex is not known, but has been suggested to assist proteasome maturation [ 35 36 ] . Our studies add Smad1, Smad1 interacting proteins such as SNIP1, Smad4, and Az as additional proteins that associate with the assembly intermediates.
The chaperon proteins such as Hsc73 could be involved in unfolding the substrates for them to fit into the degradation chamber and the final maturation of 20S proteasome from the 16S assembly intermediates could trap the substrates, such as Ump1 and Smads, inside the degradation chamber.
In addition, the prosequences still bind to the β subunits after its cleavage and may serve important chaperon roles for the β subunits to be properly positioned into assembly complex.
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