Words similar to chaperone
Example sentences for: chaperone
How can you use “chaperone” in a sentence? Here are some example sentences to help you improve your vocabulary:
It is unlikely that these alterations in alphaA/BKO mouse lenses result from increased susceptibility of these lenses to light-induced damage in the absence of the molecular chaperone protection afforded by alphaA and alphaB in normal lenses.
Export of many, but not all, secretory proteins is dependent on interaction with SecB, a cytoplasmic chaperone that maintains the preprotein in a loosely folded conformation competent for translocation.
Nucleoplasmin is the most abundant protein in the Xenopus oocyte nucleus and is the protein for which the term molecular chaperone was coined due to its multiple roles in the assembly of nucleosomes during early frog development [ 1 ] . Nucleoplasmin forms a pentamer and its stretches of acidic residues bind to histone H2A and H2B.
Substoichiometric amounts of midasin have also been detected in isolated preparations of 60S preribosomal particles suggesting that it may play a role in maturation of 60S ribosome subunits [ 2 ] . Such a role for midasin as a nuclear chaperone involved in the assembly/disassembly of macromolecular complexes in the nucleus would be consistent with our localization data and with the known functions of other AAA proteins.
Although the formation of intranuclear inclusions has not been observed in previous studies of Ras-related GTPases, it is a common feature of several neurodegenerative disorders where abnormal proteins containing poly-Gln tracts are synthesized as a result of CAG codon expansions [ 52 ] . Examples include Huntington's disease (huntingtin) [ 53 54 ] , spinocerebellar ataxia (SCA) types 1 and 3 (ataxin-1 and ataxin-3) [ 55 56 ] and dentatorubral-pallidoluysian atrophy (atrophin-1) [ 57 ] . These poly-Gln protein aggregates typically contain ubiquitin [ 58 ] and members of the Hsp70 chaperone family [ 59 ] , consistent with a proposed pathway for cellular clearance of toxic misfolded proteins.
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