Words similar to cell-cell
Example sentences for: cell-cell
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TSP-1 is a homotrimeric multidomain glycoprotein synthesized and secreted by numerous cell types, including platelets, vascular smooth muscle cells and keratinocytes [ 4 ] . Due to its interaction with a wide variety of proteins, TSP-1 has been implicated in a number of biological processes including coagulation, cell adhesion, the modulation of cell-cell and cell-matrix interactions, control of tumor growth and metastasis, and angiogenesis [ 10 ] . Inhibition of tumor cell proliferation has been achieved in vivo by systemic treatment with TSP-1 peptide mimetics [ 11 ] , but a correlation between primary tumor TSP-1 expression and poor prognosis has not been clearly established [ 12 ] . While there are reports that these molecules can originate from tumor cells [ 13 ] , the majority of reports have suggested that the major source of both TSP-1 and OPN is tumor-associated stroma [ 14 ] or infiltrating macrophages and lymphocytes [ 15 ] .
Recently, a subset of CD4 +T cells was identified that is present on 5-10% of CD4 +T cells in normal naïve mice and expresses CD25 (the α-chain of IL-2 receptor) [ 4 5 ] . Functional analysis of murine CD4 +CD25 +T cells showed that those cells, which constitutively express cytotoxic T-lymphocyte antigen (CTLA)-4 [ 6 7 8 ] , fail to proliferate or secret cytokines in response to polyclonal or antigen-specific stimulation, but inhibit the activation of conventional responsive T cells [ 1 2 3 8 9 ] . The suppressive activity of the CD4 +CD25 +T cells depends on signaling via the negative regulator of T-cell activation CTLA-4 [ 7 ] and requires a cell-cell interaction that possibly involves cell surface bound transforming growth factor (TGF)-β 1 [ 1 10 ] . It has been shown that B7/CD28 costimulation is essential for the development and homeostasis of the CD4 +CD25 +regulatory T cells [ 6 ] , which play critical roles not only in preventing autoimmunity but also in controlling tumor immunity and transplantation tolerance [ 2 11 ] .
Cells were maintained in humidified air containing 5% CO 2 for two weeks to allow for cell-cell junctions to mature.
It is generally accepted that the driving force for cell movement is provided by the dynamic reorganization of the actin cytoskeleton, directing protrusion (lamellipodia and filopodia) at the front of the cell and retraction at the rear [ 30 31 ] . Although we have not examined the ultrastructure of the dermal fibroblasts at the edge of wound sites, we showed previously by electron microscopy that in the lens of SPARC-null mice numerous cellular processes extended into the ECM of the lens capsule [ 23 ] . We further showed that, in contrast to the abnormal filopodial projections at the lens cell-ECM interface, cell-cell contacts between the neighboring lens epithelial cells and between the lens epithelial and fiber cells were normal [ 23 ] . The results indicate that disassembly of cell-cell contacts between lens cells is not taking place, despite the forward movement of the lens cells into the ECM of the capsule.
Podocyte cell-cell contact
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