Example sentences for: cell-autonomous

How can you use “cell-autonomous” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Pancreatic islets derive from embryonic endoderm, but display features of neurons, including a shared set of cell-autonomous developmental regulators [2].

  • In the Hoxa3,Pax1 compound mutants, cell-autonomous TEC defects cause a partial block at the DN-DP transition, so thymocytes do progress to DP and SP stages, albeit at reduced frequencies [ 29 ] . TEC defects are seen as early as E12.

  • Expression patterns in cultured labial skin fibroblasts derived from two different individuals with AR mosaicism suggested that the cell-autonomous AR status was a relevant determinant of baseline gene expression in genital skin fibroblasts.

  • We also analyzed two mutant strains that have either cell-autonomous ( Hoxa3 +/- Pax1 -/-) or non-cell-autonomous ( Rag1 -/-) TEC defects, with blocks at different stages of thymocyte differentiation.

  • A critical question raised by these results is whether the observed differences between genital fibroblasts from males and AIS females reflect cell-autonomous effects of androgen exposure during development, or indirect effects of the AR-dependent genital morphogenetic program.


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