Words similar to ccaf-induced
Example sentences for: ccaf-induced
How can you use “ccaf-induced” in a sentence? Here are some example sentences to help you improve your vocabulary:
Probing the same blots for Coll III revealed no cCAF-induced difference in the level of production of this protein (Fig.
We show that: (i) cCAF stimulates TN expression and that a 15 aa peptide containing the N-terminal sequence causes the same effects as the whole molecule; (ii) in contrast to its effects on TN production, cCAF-induced increase in FN and Coll I accumulation requires the whole molecule; (iii) the increase in FN protein is not a result of a corresponding increase in mRNA, or increase in MMP production or PA activity but appears to be linked TN production; (iv) increase in Coll I correlates with decreased levels of MMP-1; (v) cCAF chemoattracts fibroblasts and accelerates their migration; (vi) treatment of excision wounds with cCAF increased the levels of all three ECM molecules in the granulation tissue of wounds albeit with different dynamics.
TN-C knockout mice show decreased accumulation of FN in wounded tissue and this decrease has been hypothesized to be due to disrupted incorporation of FN into the matrix in the absence of TN-C [ 32 33 ] . To determine whether cCAF-induced TN production is involved in the increase in FN observed after cCAF treatment, we used antisense phosphothioated oligonucleotides to inhibit TN production.
Sense oligonucleotides did not have an effect on cCAF-induced TN or FN production.
Therefore, it is possible that alterations in the activities of integrins or adhesive sites on other ECM molecules induced by the whole cCAF molecule, and not by the N-peptide, could affect FN accumulation [ 47 ] . We are currently pursuing studies to determine whether adhesion molecules or other ECM molecules play a role in FN accumulation due to cCAF-induced TN production.
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