Example sentences for: ccaf

How can you use “ccaf” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • FN accumulation due to cCAF treatment also differs from that of TN.

  • It is not clear from their results whether the elevation in collagen production in normal fibroblasts may have been small, like that observed with cCAF, and therefore gone unnoticed.

  • Some of the fibroblasts differentiate into myofibroblasts, which contract to close the wound [ 4 14 15 ] . Myofibroblasts are fibrogenic, showing elevated expression of interstitial collagens, laminin, FN and TN, and inhibitors of matrix metalloproteinases such as TIMP-1 [ 15 16 17 18 19 ] . Because cCAF is expressed highly in the granulation tissue of wounds in areas where ECM is abundant [ 3 6 11 ] , and it stimulates fibroblasts to differentiate into myofibroblasts [ 4 ] , we investigated whether this chemokine stimulates the production of the four major ECM molecules mentioned above, interstitial Colls I and III, TN and cellular FN.

  • Therefore, we tested whether cCAF affects the production or activity of the gelatinases MMP-2 or MMP-9, or the collagenase MMP-1, all of which digest collagens I and III.

  • Work of others has shown that TN is expressed in association with differentiation of myofibroblasts and is important in cell migration during healing [ 25 42 43 44 ] . Here we show that cCAF and the N-peptide stimulate fibroblasts in culture to express TN and that this increase in TN is due to an increase in mRNA levels.


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