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Example sentences for: ccaf
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In adults, TN, specifically TN C, is present almost exclusively in the granulation tissue of healing wounds [ 12 24 ] . In addition to providing a matrix for rapid migration of cells during wound repair, TN supports differentiation of fibroblasts into myofibroblasts [ 25 ] , which then produce more TN than do normal fibroblasts [ 15 18 ] . Because cCAF stimulates fibroblasts to differentiate into myofibroblasts, we tested the possibility that this chemokine also affects TN production.
The left wing was treated with vehicle alone, and the right wing with 1 μg cCAF.
Some of the fibroblasts differentiate into myofibroblasts, which contract to close the wound [ 4 14 15 ] . Myofibroblasts are fibrogenic, showing elevated expression of interstitial collagens, laminin, FN and TN, and inhibitors of matrix metalloproteinases such as TIMP-1 [ 15 16 17 18 19 ] . Because cCAF is expressed highly in the granulation tissue of wounds in areas where ECM is abundant [ 3 6 11 ] , and it stimulates fibroblasts to differentiate into myofibroblasts [ 4 ] , we investigated whether this chemokine stimulates the production of the four major ECM molecules mentioned above, interstitial Colls I and III, TN and cellular FN.
In situ hybridization for cCAF showed that the migrating fibroblasts also express higher levels of cCAF (Fig.
Western blot analysis of extracts from treated fibroblasts confirmed that cCAF increases production of TN in culture, that this effect also can be accomplished effectively by the N-peptide, but that the C-peptide produced an elevated, but substantially smaller, response than either the N-peptide or the whole cCAF molecule (Fig.
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