Words similar to cation
Example sentences for: cation
How can you use “cation” in a sentence? Here are some example sentences to help you improve your vocabulary:
They are constitutively permeable to water, and also function as regulated non-selective cation channels [ 10 ] when gated by intracellular cyclic GMP [ 11 12 ] . Even though only a small proportion of the AQP1 channels that are present in the membrane appear to be available for cGMP-activation of the ionic conductance (1/56,000), model-based calculations nonetheless suggest that this contribution could be meaningful in a physiological setting [ 13 ] . Unlike transporters which move substantial amounts of substrate by design, ion channels function to change membrane potential by the net movement of relatively tiny amounts of charge (~10 picomoles per cm 2membrane to generate a change of 100 mV) [ 14 ] , hence the low proportion of active AQP1 ion channels is consistent with a functional goal of gated ionic signaling that is distinct from that of massive constitutive osmotic water permeability.
The initial MTX-induced increase in [Ca 2+] i reflects the activation of a Ca 2+-permeable non-selective cation channel (CaNSC) [ 1 4 5 6 7 8 ] . This channel, which has a reported conductance in the range of 12-40 pS depending on ionic conditions [ 5 9 10 11 ] , causes rapid membrane depolarization, which in excitable cells, leads to activation of voltage-sensitive channels.
In addition a putative cation channel was identified in the center of the protein.
To examine the effect of divalent cation composition, 8 mM MnCl 2 , was used instead of 10 mM MgCl 2 , and again no RNAseH activity was detected (data not shown).
Further analysis will be necessary to determine whether this protein functions as a regulatable cation channel.
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