Words similar to carcinogenesis
Example sentences for: carcinogenesis
How can you use “carcinogenesis” in a sentence? Here are some example sentences to help you improve your vocabulary:
The cyclooxygenase pathway and NSAIDs have been implicated in pancreatic carcinogenesis, as elevated levels of COX-2 mRNA and protein have been detected in pancreatic carcinomas relative to histologically normal cells [ 14 15 16 17 18 19 ] . Further, both aspirin [ 20 21 22 ] and other NSAIDs [ 19 ] have been shown to inhibit pancreatic cancer cell proliferation and induce apoptosis in vitro . Recent studies have also reported an association between oncogenic ras and COX-2 expression [ 23 24 ] . Since pancreatic tumors tend to exhibit a high frequency of K- ras mutations [ 25 ] , the relationship between the K- ras oncogene and COX-2 should be explored further in vivo.
3% of invasive CC, and 11% and 29% of low- and high-grade CIN lesions, respectively [ 12 ] . These authors suggest that RARB methylation is an early event in multistage cervical carcinogenesis.
[ 9 ] , but employed far greater doses of aspirin (45 and 90 mg/kg/day) and reported no dose-response relationship and a maximal suppression of 55% [ 7 ] . Furthermore, in the rat model of azoxymethane-induced colon carcinogenesis, aspirin has also only been found to inhibit aberrant crypt foci and tumour development by no more than 65% [ 4 39 ] . Coincidentally, epidemiological data also report reductions in the 40-50% range [ 13 14 15 32 ] . However, whether this can be used as an argument to support the notion that aspirin is only able to suppress tumour formation by 50% is difficult to extrapolate because two different end points are being examined (i.e.
Wnt-1 TG mice have been used to assess the functions of a number of genetic lesions in breast carcinogenesis because tumors appear with predictable kinetics.
Converging evidence from epidemiological and molecular studies suggests that infection of genital human papillomavirus (HPV) is causally linked to the development of CC [ 4 ] . Since only a small fraction of HPV-infected cervical intra-epithelial neoplastic (CIN) lesions progress to invasive cancer, these studies further suggest that in addition to HPV, other host genetic factors play a role in cervical carcinogenesis [ 5 ] . A number of molecular studies have identified genetic alterations in these two histologic types of CC and at various stages of precursor lesions [ 6 7 8 ] . Despite this molecular characterization, the genetic basis of CC initiation and progression is still very poorly understood.
Loading...