Words similar to carbenoxolone
Example sentences for: carbenoxolone
How can you use “carbenoxolone” in a sentence? Here are some example sentences to help you improve your vocabulary:
Glycyrrhetinic acid is an aglycone saponin extracted from licorice root [ 7 ] and saponines have hypnotic effects [ 17 ] . Carbenoxolone is also the succinyl ester of glycyrrhetinic acid.
Less is known about the effects of carbenoxolone on GJs, although it has been proposed that glycyrrhetinic acid, to which carbenoxolone is related, binds directly to connexin molecules causing a conformational change leading to a closure of the junction [ 7 ] . Modeling studies indicate that neuronal synchronization can be mediated by low densities of GJs either between dendrites, as long as these dendrites are excitable [ 10 ] , or between the axons of pyramidal cells [ 11 ] . Furthermore, the electrotonic coupling could be promoted during epileptogenesis [ 12 13 ] .
Present results indicate that carbenoxolone has anticonvulsant activities in PTZ and MES models.
Thus, we considered the possible anticonvulsant effect of carbenoxolone in animal seizure models.
Diazepam, carbenoxolone and normal saline were injected intraperitoneally (i.p) 30, 60 and 60 min respectively, before the administration of pentylenetetrazole (i.p, 90 mg/kg).