Example sentences for: carbenoxolone

How can you use “carbenoxolone” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In maximal electroshock (MES) model, carbenoxolone (400 mg/kg) decreased the duration of tonic seizures.

  • In in vitro studies, carbenoxolone abolished the generation of full or partial ectopic spike generation, by 4-AP, in the CA 3 region of rat hippocampal slices [ 6 ] . Also carbenoxolone depresses spontaneous epileptiform activity in the CA 1 region of rat hippocampal slices [ 7 ] . Carbenoxolone appears to cross the blood brain barrier about one hour after an intraperitoneal injection in rats as there was the inhibition of 11-β-hydroxysteroid dehydrogenase in multiple brain regions [ 1 ] . It and/or its congener glycyrrehetinic acid may also enter the eyes of humans.

  • In the potentiation of pentobarbitone sleep test, carbenoxolone significantly showed sedative effect.

  • In the traction test, carbenoxolone did not induce a muscle relaxant activity significantly up to a dose of 400 mg/kg.

  • Glycyrrhetinic acid is an aglycone saponin extracted from licorice root [ 7 ] and saponines have hypnotic effects [ 17 ] . Carbenoxolone is also the succinyl ester of glycyrrhetinic acid.


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