Words similar to carbenoxolone
Example sentences for: carbenoxolone
How can you use “carbenoxolone” in a sentence? Here are some example sentences to help you improve your vocabulary:
In maximal electroshock (MES) model, carbenoxolone (400 mg/kg) decreased the duration of tonic seizures.
In in vitro studies, carbenoxolone abolished the generation of full or partial ectopic spike generation, by 4-AP, in the CA 3 region of rat hippocampal slices [ 6 ] . Also carbenoxolone depresses spontaneous epileptiform activity in the CA 1 region of rat hippocampal slices [ 7 ] . Carbenoxolone appears to cross the blood brain barrier about one hour after an intraperitoneal injection in rats as there was the inhibition of 11-β-hydroxysteroid dehydrogenase in multiple brain regions [ 1 ] . It and/or its congener glycyrrehetinic acid may also enter the eyes of humans.
In the potentiation of pentobarbitone sleep test, carbenoxolone significantly showed sedative effect.
In the traction test, carbenoxolone did not induce a muscle relaxant activity significantly up to a dose of 400 mg/kg.
Glycyrrhetinic acid is an aglycone saponin extracted from licorice root [ 7 ] and saponines have hypnotic effects [ 17 ] . Carbenoxolone is also the succinyl ester of glycyrrhetinic acid.