Example sentences for: carbapenems

How can you use “carbapenems” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • When the carbapenems were used as substrates however, the changes in K m values were relatively smaller than with the other substrates, and 2- to 37-fold changes in k cat were observed (Table 5).

  • The Tyr228 mutants exhibited increased K m values for 8 of the 9 substrates tested, with the smallest changes in K m observed when the carbapenems were used as the substrate.

  • This mutation is also predicted to affect the hydrogen bonding network around the active site, and apparently, interactions of the enzyme with the 4' substituent of the carbapenems has an effect on catalysis.

  • Interestingly, there was a 2- to 8-fold drop in k cat values for the Tyr228 mutants, as compared to values observed for wild-type L1, when using the carbapenems as substrates.

  • L1's preference for penicillins and carbapenems over cephalosporins, as exemplified by the k cat values, is in agreement with previous studies and supports L1's placement in the β-lactamase 3c family [ 9 ] .


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