Words similar to calbindin

Example sentences for: calbindin

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This cell line spontaneously differentiates in culture and expresses biochemical and morphological characteristics of well-differentiated small intestine-like enterocytes [ 17 23 ] . We have previously shown that Caco-2 cells possess a classical nuclear vitamin D receptor [ 18 ] that directly mediates vitamin D-dependent gene expression [ 22 ] , and exhibits a high degree of specificity for various vitamin D metabolites and analogs [ 20 21 ] . Most importantly, in response to short-term (<24 h) 1,25-dihydroxyvitamin D treatment, Caco-2 cells increase transepithelial calcium transport [ 17 ] and calbindin D 9K expression [ 19 ] , a cytosolic calcium binding protein.
CaT1 induction precedes the increase in calbindin D 9kmRNA expression
GAPDH was amplified for 21 cycles, CaT1 for 28 cycles and calbindin D 9K for 28 cycles.
As illustrated in Figure 5, the time course of vitamin D-dependent mRNA induction of the two genes clearly differs with CaT1 expression responding much earlier than calbindin D9k.
Given what is already known about the characteristics of the epithelial calcium channels and calbindin D, it is a plausible hypothesis that CaT1 and calbindin D could work in tandem to maintain high rates of calcium absorption.