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Example sentences for: buffergel
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Such activity was reported for dextran sulfate after 2 h incubation with HIV-1 [ 2 ] but results of other studies indicated that dextran sulfate failed to neutralize virus infectivity [ 4 10 ] . Inactivation of HIV-1 by carrageenan was reported in a review article [ 18 ] . BufferGel is virucidal against HIV-1 by providing a buffered low pH environment (pH 3.9 [ 25 ] ), but virus inactivation might be incomplete and possibly compromised by minor pH increases due to the presence of seminal fluid [ 40 ] . To be effective in preventing infection by direct virus inactivation, anti-HIV-1 microbicides must be virucidal against both X4 and R5 viruses, utilizing CXCR4 and CCR5 as coreceptors [ 39 41 ] , respectively, R5 HIV-1 being most frequently sexually transmitted.
In repeated experiments with HIV-1 IIIB, soluble and micronized CAP, cellulose sulfate, poly(naphthalene sulfonate), poly(styrene-4-sulfonate) and BufferGel, respectively, caused a ≥ 140-fold reduction in infectivity, while dextran sulfate, carrageenan and Carbomer 974P (pH 7), respectively, were less effective (4- to 25-fold reduction in infectivity).
They include: (1) sulfate esters of polysaccharides {carrageenan [ 1 16 17 18 19 ] , cellulose sulfate [ 12 13 14 15 ] , and dextran or dextrin sulfate [ 1 2 3 4 5 6 7 8 9 10 11 ] }; (2) aryl sulfonates {poly(naphthalene sulfonate) [ 22 23 24 ] and poly(styrene-4-sulfonate) [ 20 21 ] }; and (3) aliphatic {Carbomer 974P/BufferGel [ 25 26 27 28 29 ] } and aromatic carboxylates {CAP [ 30 31 32 33 34 35 36 37 ] }. The anti-HIV-1 properties of these polymers are expected to depend on their complexation with virus proteins which is likely to occur mainly through the formation of salt linkages or ion pairs between oppositely charged groups on the polymers and virus proteins, respectively [ 56 ] . However, the anti-HIV-1 properties of these polymers may depend not only on their charge density, but also on the characteristics of their uncharged portions, which may be involved in hydrophobic and hydrogen bonding interactions which can elicit profound conformational changes in hydrophobic regions of proteins and cause disassembly of complex proteins consisting of subunits [ 57 ] . For these reasons it is not be expected that all anionic polymers, considered as anti-HIV-1 microbicides, would have similar biological activities.
Among anionic polymers considered as topical microbicides to prevent sexual transmission of HIV-1 {Carbomer 974P/BufferGel, carrageenan, CAP, cellulose sulfate, dextran/dextrin sulfate, poly(napthalene sulfonate) and poly(styrene-4-sulfonate)}, CAP formulated in a micronized form, is the only compound which has a capacity to remove from physiological fluids infectious virus by adsorption onto the micronized particles.
BufferGel was a gift from Dr. Kevin J. Whaley, John Hopkins University.
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