Words similar to breakthrough

Example sentences for: breakthrough

How can you use “breakthrough” in a sentence? Here are some example sentences to help you improve your vocabulary:

In Yardley's affectionate yet dubious portrait of a man he knew only through rambling late-night phone calls, Exley was a classic one-hit wonder, a writer who never overcame his breakthrough.
But O'Brien, who has always been opposed to making deals with Sinn Fein, noted that there was now less open emphasis in Ireland on peace than on a breakthrough for Irish nationalism, and he added that an article in the Sunday Business Post--the Dublin newspaper most sympathetic to Sinn Fein--had rather given the game away with an article that said, "[T]he IRA, which is likely to maintain its ceasefire for several months, will almost certainly resist any attempt to accede to unionist demands for actual decommissioning of weapons by early summer."
So why don't I hail Hillary's candidacy as an important feminist breakthrough?
Thus, determination of the structure of KirBac would be a major breakthrough in understanding the structure and functional mechanisms of this important family of K +channels.
Alternatively, if a breakthrough of virus replication was observed, this would provide a boost in HIV-1-specific immunity after reinstitution of antiviral therapy.