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Example sentences for: breakpoints
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For example, the KRC/ZAS-C consensus sequence "ATTTTGTGG" matches completely with 6 nucleotides of the RSS nonamer and 3 flanking nucleotides of the human IgH D1, D2, D3 and D4 gene segments [ 35 ] . Furthermore, the MAST search identified KRC-selected motifs near two chromosomal breakpoints: between a t(11:14) translocation of the Ig DH2-2 gene segment and the B cell lymphoma 1 ( BCL-1 ) gene in a mantle cell lymphoma [ 36 ] , and at a t(11:19) translocation of the myeloid lymphoid leukemia ( MLL ) gene and the ENL/MLLT1/LTG19 gene in a T-cell acute lymphoblastic leukemia [ 37 ] . The other hits were derived from loci of cellular genes, pseduogenes, or DNA fragments [ 41 42 43 44 ] . The expression of those genes has not been shown to be regulated by KRC or other family members, therefore, the biological significance of those MAST results is unknown.
The usefulness of RI strains for mapping is largely a function of the number of known recombination breakpoints and useful polymorphisms that they harbor.
Particular attention was paid to the position of each probe with respect to the three large low-copy repeat clusters found within 15q11-q13; as these clusters contain both inter- and intrachromosomal segmental duplications, and correspond to the common deletion breakpoints of Prader-Willi and Angelman syndrome deletions [ 12 13 21 32 ] . The duplication track of the UCSC Genome Browser, August 2001 assembly, displays information obtained from a global analysis of segmental duplications in the human genome, and allows for the selection of informative unique clones [ 14 16 ] . In this manner, we selected probes flanking the human 15q11-q13 rearrangement breakpoints associated with common PWS/AS deletions.
A better test of this approach to choosing the breakpoints is described below where an input that is clearly not a gamma distribution is used.
Figure 13shows the fit using this default set of breakpoints (using the gamma distribution approximation) and smoothing parameter ( = 1) for the same 3 noisy data sets that were used for the analytical (fig.
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