Words similar to breakpoint

Example sentences for: breakpoint

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Before this study only a single fixed inversion breakpoint had been characterized at the sequence level in Drosophila [ 24].
Recent studies have characterized several evolutionary breakpoints in common chimpanzee and other great ape species including pericentric inversions and a chromosome translocation [ 7 8 9 ] . We present here a refinement of the breakpoint associated with a previously identified pericentric inversion of the human 15q11-q13 orthologous region in common chimpanzee (XVp) to a region containing multiple segmental duplications [ 1 2 10 ] .
While public and private sequence assemblies now depict the correct location for this gene, previous published reports indicated that this gene mapped proximal to BP3 within the PWS/AS deletion and autism-associated interstitial duplication interval [ 21 22 ] . STS content mapping with regional clones confirms the predicted genomic assemblies and places this gene distal to the BP3 HERC2-containing breakpoint.
Using the most current assembly of the human genome available, build 31 - released November 2002 - probes adjacent to and overlapping RP11-40J8 were used in further FISH experiments to characterize and more precisely define the breakpoint interval (Figure 3).
Conversely, probe RP11-736I24 hybridized to HSA and PTR XVq, indicating the pericentric inversion breakpoint likely lies proximal of this position in the human assembly.