Words similar to breakpoint

Example sentences for: breakpoint

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We investigated the L1 sequence composition at the breakpoint in 5' truncated L1s by collecting 15 nucleotides of L1 sequence upstream and downstream of the position at which the L1 had been truncated; we were unable to detect any consensus nucleotides at these breakpoints (data not shown).
3 and the fact the CHRNA7 duplication appeared polymorphic in the human population [ 17 ] . This hypothesis deserved consideration in this study, as the site of duplication of the CHRNA7 locus in the human genome may correspond to the pericentric inversion breakpoint, and the high sequence homology noted between the donor and duplicated CHRNA7 loci does not establish the human-specificity of the CHRNA7 duplication, as gene conversion may also maintain high sequence homology of duplicated segments [ 26 27 ] . Thus, we tested the chimpanzee genome by Southern genomic analysis for the presence of the CHRNA7 duplication which revealed this duplication is most likely human-specific and therefore did not contribute to the pericentric inversion in chimpanzee (Figure 5).
This may result from imprecision in the assignment of the 5' breakpoint.
Before this study only a single fixed inversion breakpoint had been characterized at the sequence level in Drosophila [ 24].
This analysis was performed on the subset of the inverted L1 segment pairs that exhibited a 'flawless' breakpoint (no deletion, insertion, or microhomology, Figure 5).