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Example sentences for: breakpoint
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Using a panel of FISH probes spanning several known sites of rearrangement within 15q11-q13 we were able to narrow the region containing the PTR pericentric inversion breakpoint to a complex cluster of segmental duplications approximately 600 kb in length, according to the most recent assembly of the human genome.
50 μg/ml) and to ACV (results not shown) according to the standard resistance breakpoint criteria, whereas isolates from mice treated with VCV had PCV IC 50 s ranging from 0.31-8.
There are two proximal breakpoints (BP1 and BP2) that define two classes of PWS/AS deletion [ 14 ] . The common distal breakpoint is termed BP3 and has a bipartite structure [ 15 16 ] . The BP2 and BP3 duplicons span several hundred kb and contain at least seven expressed sequences.
This analysis was performed on the subset of the inverted L1 segment pairs that exhibited a 'flawless' breakpoint (no deletion, insertion, or microhomology, Figure 5).
To mark the regions of low-copy repeats in human 15q11-q13, we utilized a probe derived from the donor locus of a major component of the PWS/AS breakpoint duplication clusters, PAC clone pDJ-778A2 which contains a significant portion of the HERC2 gene in 15q13 [ 33 ] . In addition, we selected probes corresponding to sites distal to the PWS/AS domain flanking a large inverted-duplicated 15 (inv dup(15)) supernumerary marker chromosome [ 23 ] . Specifically, probe RPCI-11-88O16 (abbreviated RP11-88O16) was selected for FISH analysis because it lies distal to the inversion-duplication event breakpoint and is linked to STS marker D15S1010 [ 23 24 ] . Upon reaching the PTR inversion breakpoint interval with probe RP11-40J8, flanking BACs were chosen from the November 2002 human genome assembly to establish the extent of the interval and define the boundaries of the interval.
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