Words similar to breakpoint
Example sentences for: breakpoint
How can you use “breakpoint” in a sentence? Here are some example sentences to help you improve your vocabulary:
deconvolution:table([usedata = 3,fitfunc = 2,plotinput = 1,Nexp = 3,breakpoint = 5, scale_smooth= 1]);
Although human chromosome 15q11-q13 is noted for its exceptional instability, associated with human disease and chromosomal rearrangement, it is noteworthy that the orthologous site of rearrangement in the human genome did not correspond to one of the three major previously described common disease rearrangement breakpoints [ 11 12 21 22 ] . Similarly, probe RP11-88O16, distal of the previously characterized inv dup(15) breakpoint, and probes RP11-456J20 and RP11-758N13, which flank an additional inv dup(15) rearrangement breakpoint (S.
There are two proximal breakpoints (BP1 and BP2) that define two classes of PWS/AS deletion [ 14 ] . The common distal breakpoint is termed BP3 and has a bipartite structure [ 15 16 ] . The BP2 and BP3 duplicons span several hundred kb and contain at least seven expressed sequences.
Probes were selected that flank known sites of genomic rearrangement based upon previous yeast artificial chromosome (YAC) and BAC/PAC mapping studies, together with the human sequence map available from the University of California at Santa Cruz (UCSC) Genome Browser [ 11 12 13 14 15 ] . Probes flanking the Prader-Willi/Angelman syndrome breakpoints, in addition to a characterized inv dup(15) rearrangement were selected to test the possibility that the pericentric inversion evolutionary breakpoint corresponded to a site of known human genomic instability (Figure 1).
Instead, our findings support the recently proposed twin-priming model for inversion [ 47]; as we showed above, the 3' end top-strand cleavage product has a modest bias to be a 'T' nucleotide (Figure 3b) and we indeed see a modest preference for a complementary 'A' nucleotide at the corresponding position of the inversion breakpoint (data not shown).
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