Words similar to bmps
Example sentences for: bmps
How can you use “bmps” in a sentence? Here are some example sentences to help you improve your vocabulary:
Although little is known about the physiology and biology of ovarian SC, they have been linked to the genesis of ovary cancer through distinct TGF-β signaling pathways [ 42 43 ] . Significantly, the importance of FS in the genesis of this cancer has been established [ 44 ] . Given the evidence that BMPs are potent growth factors and that FS can modulate their bioactivity, it will be interesting to investigate the possibility that this intrinsic BMP system may be involved to pathogenesis of SC tumors.
First, in a separate report, we showed that Smad1 itself is targeted to proteasome and is subsequently degraded by the proteasome, an event that is triggered by the activation of BMP type I receptor and involves the targeting role of Az and HsN3 [ 39 ] . Proteasomal degradation of Smad1 appears to also play a role in regulating the constitutive level of Smad1 in cell as a way to adjust the cellular responsiveness of BMPs [ 47 ] . However, the targeting mechanism and the regulation involved in these two cases of Smad1 degradation by proteasome are likely fundamentally different [ 39 ] . The second functional outcome of the physical link between Smad1, HsN3 and Az is the ability of Smad1 to regulate the proteasomal degradation of SNIP1, which is clearly dependent upon high levels of Smad1, Az and a strong activation signal from the type I receptor, as suggested by the observations that the protein levels of Smad1, Az and ALK3Q233D directly influence the degree of SNIP1 degradation.
To determine the functional significance of the observed SNIP1 degradation induced by BMPs, we tested the role of SNIP1 in Smad1-regulated gene responses of BMPs.
Their molecular properties were at first surprising: they proved to be antagonists of other signaling factors, mostly of bone morphogenetic proteins (BMPs) and also of WNT (a secreted protein homologous to the
Recent data suggest that in the developing nervous system, signaling by at least BMPs 2, 4 and 7 is determined by the spatiotemporal expression patterns of BMPs and their receptors, and by relative levels of the soluble BMP antagonists such as follistatin and noggin that directly bind BMPs in the extracellular compartment and prevent functional receptor/ligand interaction [ 1 24 25 26 27 28 ] . The extent to which these factors may regulate BMP-5 signaling is difficult to determine because of the paucity of data regarding either antagonism of BMP-5 signaling by follistatin and noggin or the interaction between known BMP receptors and BMP-5.
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