Words similar to bmps
Example sentences for: bmps
How can you use “bmps” in a sentence? Here are some example sentences to help you improve your vocabulary:
First, in a separate report, we showed that Smad1 itself is targeted to proteasome and is subsequently degraded by the proteasome, an event that is triggered by the activation of BMP type I receptor and involves the targeting role of Az and HsN3 [ 39 ] . Proteasomal degradation of Smad1 appears to also play a role in regulating the constitutive level of Smad1 in cell as a way to adjust the cellular responsiveness of BMPs [ 47 ] . However, the targeting mechanism and the regulation involved in these two cases of Smad1 degradation by proteasome are likely fundamentally different [ 39 ] . The second functional outcome of the physical link between Smad1, HsN3 and Az is the ability of Smad1 to regulate the proteasomal degradation of SNIP1, which is clearly dependent upon high levels of Smad1, Az and a strong activation signal from the type I receptor, as suggested by the observations that the protein levels of Smad1, Az and ALK3Q233D directly influence the degree of SNIP1 degradation.
Although it is becoming clear that intrinsic BMPs are important players in the ovary, the cellular localization of BMPs in the ovary is poorly understood, and a proper understanding of how the cell-specific expression of the BMP system changes during the cycle is still lacking.
As part of our ongoing investigations of the roles of BMPs in ovary physiology, we have analyzed the spatiotemporal expression patterns of the BMP system in the rat ovary cell types during the normal estrous cycle.
The bone morphogenetic proteins (BMPs) are multi-functional regulators of early embryogenesis and tissue/organ morphogenesis.
Functional characterization of the interaction between Smad1, Az and HsN3 in the signaling pathways of BMPs led us to find a novel functional link between Smad1 and proteasome-mediated degradation events, through which a novel CBP/p300 repressor, SNIP1 [ 25 ] , is removed to allow the transcriptional activation of BMP-responsive genes.
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