Words similar to bmpr-ia-fc

Example sentences for: bmpr-ia-fc

How can you use “bmpr-ia-fc” in a sentence? Here are some example sentences to help you improve your vocabulary:

The latter was evaluated indirectly using a recombinant chimeric protein containing the extracellular domain of the BMP receptor type IA fused to the immunoglobulin Fc domain (BMPR-IA-Fc).
Data from western blot analyses using Ab specific for phosphorylated epitopes of Smad-1 as well as analyses of dendritic growth in cultures exposed to BMP-5 in the presence of a soluble BMPR-IA-Fc chimeric protein are consistent with a signaling pathway that involves binding to the BMPR-IA and activation of Smad-1.
The BMPR-IA-Fc chimera also significantly inhibited BMP-5-induced dendritic growth.
BMPs activate Smad-1 by binding to type I and type II serine-threonine kinase receptors [ 40 41 ] . Specific receptor subunits shown to bind BMPs include BMP receptor type IA (BMPR-IA), BMPR-IB, BMR-II, activin receptor type I (ActR-I), and ActR-II [ 42 43 44 ] . BMP ligands can bind to either type I or type II receptor subunits independently, but both receptor types are required for high-affinity binding and signaling [ 40 ] . The finding that the soluble BMPR-IA-Fc chimera significantly inhibits BMP-5 induced dendritic growth suggests that BMP-5 may be activating the Smad-1 signaling pathway via interactions with BMPR-IA.