Words similar to bmpr-ia
Example sentences for: bmpr-ia
How can you use “bmpr-ia” in a sentence? Here are some example sentences to help you improve your vocabulary:
First, we found that the genes encoding the BMP receptors (BMPR-IA, -IB, -II) are highly expressed in the DF throughout its course of development.
The bone morphogenetic protein (BMP) family including ligands, receptors, and binding proteins, has emerged as a central player in ovary physiology and female fertility [ 1 ] . The BMPs represent a large subclass of the transforming growth factor-β (TGF-β) surperfamily of ligands whose biological responses are mediated by Ser/Thr kinase receptors via the Smad-signaling molecules [ 2 ] . The mRNAs encoding several BMP family members have been identified in the murine ovary, including the ligands, BMP-2 [ 3 ] , BMP-3 [ 3 ] , BMP-3b [ 3 ] , BMP-4 [ 4 ] , BMP-6 [ 5 ] , BMP-7 [ 4 ] , BMP-15 [ 6 7 8 ] , the BMP receptors, BMPR-IA, BMPR-IB and BMPR-II [ 4 ] and the BMP binding protein, follistatin (FS) [ 9 ] . In the murine, BMP-4 and -7 mRNA have been identified in the theca interstitial cells [ 4 ] , BMP-6 and -15 in oocytes [ 5 6 7 8 ] , BMPR-IA, BMPR-IB and BMPR-II in oocytes and granulosa cells (GCs) [ 4 ] , and FS in granulosa and lutein cells [ 9 10 ] .
Our data show that the primary/secondary transition stage is accompanied by some rather dramatic changes in BMP expression including increased expression of: i) BMP-6, BMP-15, and BMPR IB in the oocyte; ii) BMP-2, BMP-6, and BMPR-IA, -IB and -II in the GC; and iii) BMP-4 and BMP-7 in the theca.
The observation that the ovarian sex cords (SC) express an intrinsic BMP system replete with ligands (BMP-3b, -4, -7) and receptors (BMPR-IA, -IB, -II) is novel.
In atretic follicles, BMPR-IA mRNA was highly expressed (Fig.
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