Words similar to bmpr-ia

Example sentences for: bmpr-ia

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BMPs activate Smad-1 by binding to type I and type II serine-threonine kinase receptors [ 40 41 ] . Specific receptor subunits shown to bind BMPs include BMP receptor type IA (BMPR-IA), BMPR-IB, BMR-II, activin receptor type I (ActR-I), and ActR-II [ 42 43 44 ] . BMP ligands can bind to either type I or type II receptor subunits independently, but both receptor types are required for high-affinity binding and signaling [ 40 ] . The finding that the soluble BMPR-IA-Fc chimera significantly inhibits BMP-5 induced dendritic growth suggests that BMP-5 may be activating the Smad-1 signaling pathway via interactions with BMPR-IA.
In atretic follicles, BMPR-IA mRNA was highly expressed (Fig.
In this regard, a recent study has demonstrated the ability of BMP-4 to inhibit cyclic AMP-stimulated androgen production by the cultured human theca cell line, presumably by activating BMP receptors (BMPR-IA, -IB, and -II) which are expressed in these cells [ 34 ] . Because theca derived androgen is required for follicle estrogen biosynthesis and has been implicated in ovary pathology [ 35 ] , it will be interesting to determine how the expression and functions of these TIC-specific BMPs are integrated into the overall processes of physiology and pathophysiology.
Expression of BMPR-IA mRNA
First, we found that the genes encoding the BMP receptors (BMPR-IA, -IB, -II) are highly expressed in the DF throughout its course of development.