Words similar to blocker
Example sentences for: blocker
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Just as modern bioinformatics provides immense databases and search tools for molecular structures and polymer sequences [ 16], we envisage that with suitable computational implementation, distributed online models may be queried not only for local pairwise interactions (such as site-site interactions) but also for long-distance chains of events (for example 'Find models where a potassium channel blocker affects cell-cycle progression'), a capability not available in any other approach to biological systems.
Figure 6Bdemonstrated that hyperthermic γ-oscillations disappear in the presence of an intracellularly delivered Na +channel blocker (QX 314, 30 mM).
Data presented here show that TEA is effective as a blocker of AQP1 channels expressed in a mammalian renal cell line and in native renal epithelial membrane.
Expression of AQP1 channels in bilayers has shown that the water permeability but not the ionic conductance is blocked by p-chloromethylbenzenesulfonate, indicating that the two fluxes may involve distinct pathways [ 12 ] . Work presented here provides an additional line of evidence that the pathways for water and ions in AQP1 can be distinguished pharmacologically, using the blocker TEA as a probe.
Tetraethylammonium is known as a pore-occluding blocker of voltage-gated potassium channels [ 1 ] , but it also blocks other cationic channels such as calcium-dependent K +channels [ 2 3 ] and the nicotinic acetylcholine receptor [ 4 ] . TEA at 0.1 to 10 mM also inhibits osmotic water flux through human AQP1 channels expressed in Xenopus oocytes, decreasing the net swelling rate in hypotonic saline by 30-40% as compared to AQP1-expressing oocytes not treated with TEA [ 5 ] . This blocking effect on osmotic water flux was demonstrated to involve AQP1 channels specifically by using site-directed mutagenesis (tyrosine 186 to phenylalanine) to generate a Y186F AQP1 channel that is insensitive to block by TEA, but retains sensitivity to block by mercury.
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