Words similar to blocker
Example sentences for: blocker
How can you use “blocker” in a sentence? Here are some example sentences to help you improve your vocabulary:
Medline was searched from 1966 to the present with the key words "doxazosin," "prazosin," "terazosin," "adrenergic alpha-antagonists," or "alpha blocker."
Tetraethylammonium is known as a pore-occluding blocker of voltage-gated potassium channels [ 1 ] , but it also blocks other cationic channels such as calcium-dependent K +channels [ 2 3 ] and the nicotinic acetylcholine receptor [ 4 ] . TEA at 0.1 to 10 mM also inhibits osmotic water flux through human AQP1 channels expressed in Xenopus oocytes, decreasing the net swelling rate in hypotonic saline by 30-40% as compared to AQP1-expressing oocytes not treated with TEA [ 5 ] . This blocking effect on osmotic water flux was demonstrated to involve AQP1 channels specifically by using site-directed mutagenesis (tyrosine 186 to phenylalanine) to generate a Y186F AQP1 channel that is insensitive to block by TEA, but retains sensitivity to block by mercury.
Just as modern bioinformatics provides immense databases and search tools for molecular structures and polymer sequences [ 16], we envisage that with suitable computational implementation, distributed online models may be queried not only for local pairwise interactions (such as site-site interactions) but also for long-distance chains of events (for example 'Find models where a potassium channel blocker affects cell-cycle progression'), a capability not available in any other approach to biological systems.
Results presented here show that TEA serves as an effective, though partial, blocker of the osmotic water permeability mediated by human AQP1 channels expressed in a heterologous mammalian cell line and by native AQP1 channels in isolated rat renal descending thin limbs of Henle's loops.
A double-blind, active-controlled hypertension component is designed to compare the rate of fatal coronary heart disease (CHD) or nonfatal myocardial infarction (MI) (the primary endpoint) in high-risk hypertensive participants, aged 55 years or older, between those randomized to treatment initiated with a diuretic (chlorthalidone) and treatment initiated with each of three alternative antihypertensive drugs: a calcium-channel blocker (amlodipine), an angiotensin-converting enzyme (ACE)-inhibitor (lisinopril), or an alpha-adrenergic blocker (doxazosin).
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