Example sentences for: blocker

How can you use “blocker” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • And when given the choice between a placebo and the cannabinoid blocker, rats choose the blocker.

  • , carteolol, had normal calcium cycling, normal myocardial energetics,normal β 1 receptor density as well as regression of myocytehypertrophy and reduced connective tissue content [ 18 ] . Furthermore, administration of carteolol hasbeen reported to prevent the development of virally induced cardiomyopathyin a murine model [ 25 ] . In a canine modelwith left ventricular dysfunction produced by multiple sequentialintracoronary microembolizations, long term treatment with metoprolol,a β 1 -selective blocker, has been reported to preventthe progression of LV systolic dysfunction and LV chamber dilatation [ 26 ] . Similarly, our present findings onthe effect of carvedilol indicated improvement of left ventricularfunction and smaller LV volumes.

  • Expression of AQP1 channels in bilayers has shown that the water permeability but not the ionic conductance is blocked by p-chloromethylbenzenesulfonate, indicating that the two fluxes may involve distinct pathways [ 12 ] . Work presented here provides an additional line of evidence that the pathways for water and ions in AQP1 can be distinguished pharmacologically, using the blocker TEA as a probe.

  • Data presented here show that TEA is effective as a blocker of AQP1 channels expressed in a mammalian renal cell line and in native renal epithelial membrane.

  • Many studies have shown that chronic intravenous infusion of norepinephrine is sufficient to cause hypertrophy, and that various forms of hypertrophy are linked to a decrease in either beta-adrenergic receptor density or a decreased responsiveness to beta-adrenergic stimulation [ 46 48 49 56 57 58 59 60 61 62 63 ] . Barth, for example, showed that norepinephrine infusion induced left ventricular hypertrophy that could be prevented by an adrenergic-receptor blocker [ 58 ] . It has been suggested that ornithine decarboxylase is a link between beta-adrenoreceptors and stimulation of tissue growth factor, which results in hypertrophy [ 64 ] . However, recent studies have focused on alpha-adrenergic reception as a mediator of cardiac hypertrophy [ 35 ] , although some question the role of the alpha-adrenergic receptor as a hypertrophic mediator in vivo [ 34 ] . To date, no published studies of which we are aware have examined alpha-adrenergic reception and the development of cardiac hypertrophy with iron deficiency.


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