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Example sentences for: blocker
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These four transcripts are considered to be biomarkers of the SU5416 administration regimen rather than activity of SU5416 specifically; with the available samples we could not exclude the possibility that altered gene expression resulted from exposure to the administration vehicle (Cremophor) or the concomitant premedications (dexamethasone and H1- and H2-blocker antihistamines) rather than SU5416.
This inhibitory effect by PMA appeared to be independent of PKC since addition of the PKC blocker, BIM (1 μM) did not prevent PMA-induced inhibition (Fig.
Optical imaging of neural activity evoked by electrical stimulation in the cultured rat suprachiasmatic nucleus (SCN) revealed that the spread of depolarization was inhibited by gap junction blockers (halothane, octanol) but not by a blocker of voltage-depended Na +channels.
Expression of AQP1 channels in bilayers has shown that the water permeability but not the ionic conductance is blocked by p-chloromethylbenzenesulfonate, indicating that the two fluxes may involve distinct pathways [ 12 ] . Work presented here provides an additional line of evidence that the pathways for water and ions in AQP1 can be distinguished pharmacologically, using the blocker TEA as a probe.
Phyllanthus urinaria plant was used by Caribs with other plants in a bath against bad luck (called 'piai') [ 66 ] . Pharmacological activities of various compounds in some species of Phyllanthus include analgesic, antiinflammatory, antilipoxigenase, antiallergic, nitrosamina blocker, aldose reductase inhibitor, antiviral, mitochondrial ATPase inhibitor, phosphodiesterase inhibitor and cyclooxigenase inhibitor [ 111 ] . Other activities are hepatoprotective, phosphorilase and tirosine kinase inhibitor, phospholipase A 2 inhibitor and increased the survival of hepatocellular carcinoma harbouring animals [ 54 111 113 112 ] . The compound with hepatoprotective activity is triacontanol [ 114 ] . Several compounds found in Phyllanthus species, like flavonoids (quercetin, rutin), tannins (geraniin, furosin), benzenoids (ethyl gallate, methyl gallate) and phytosterols showed antinociceptive effects in mice or multiple mechanisms of action [ 111 115 ] . The flavonoids also have anti-inflammatory properties [ 38 11 ] . The hydroalcoholic extracts of four Phyllanthus species were 2 - 6 fold more active in causing antinociception than aspirin depending on the route of administration and the pain model used [ 115 ] . Phyllanthus amarus has antioxidant properties, reverses chromosomal alterations induced by genotoxic agents and has anticancer activity [ 112 ] . Active compounds may be flavonoids (quercetin, astragalin), ellagitannins (amarinic acid), hydrolysable tannins (phyllanthisiin D) [ 112 ] . The multiple plant compounds found in Phyllanthus species might help clear up any physiological condition that results in dogs having difficulty following game animals.
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