Words similar to biomarkers
Example sentences for: biomarkers
How can you use “biomarkers” in a sentence? Here are some example sentences to help you improve your vocabulary:
The mouse homologue of one of the candidate biomarkers, LNC2, has been shown to be regulated at the transcriptional level by dexamethasone in murine cells [ 22 ] . However, there is no published evidence that the human LCN2 gene is likewise dexamethasone-inducible, and there is no description of glucocorticoid-responsive elements in the 5' regulatory region of the human LCN2 gene [ 28 ] . Further, preliminary investigation in our laboratory, using in vitro cultures of purified PBMCs from healthy volunteers, indicates that neither the LCN2 gene nor any of the other 3 transcripts is directly inducible by acute treatment with either SU5416 or dexamethasone (data not shown).
These guidelines should greatly help investigators design and analyze nested case-control studies for early detection biomarkers and help readers of the literature to interpret them.
The varying amounts of isotypes in these tissue samples suggest that isotype levels might be correlated with other biomarkers of poor prognosis.
Since it will not be possible to test many agents in large randomized clinical trials, efforts are underway to develop useful tissue-based surrogate end-point biomarkers that can be used to select only the most promising agents (and doses) for large-scale trials.
Mining the dataset with other analytical approaches might lead to a different set of potential biomarkers.