Words similar to binding-site
Example sentences for: binding-site
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Computational approaches can therefore be used to detect and model the sequence patterns present within the binding-site variability.
Direct biological models of binding-site organization in TCRs, as exemplified by conserved word-pair templates, provided several advantages over naive statistical models based on sequence combinations in S. cerevisiae . Average gene-expression profiles showed that conserved word pairs were more specific predictors of gene expression (giving fewer false positives) than single or pairwise sequences derived from S. cerevisiae , indicating that conserved regions among these closely related Saccharomyces species were enriched for functional sequences.
However, unlike binding-site clusters, CNCS clusters can be rapidly identified in the absence of any a priori information about transcription factor specificity, and may therefore provide a more general approach to genome-wide cis -regulatory prediction.
The consideration of distance constraints between pairs of conserved sequences found many more examples than a previous study of binding-site clustering for multiple transcription factors in S. cerevisiae [ 22 ] . In addition, we discovered new sequences and pairwise interaction terms using regression models similar to those reported in [ 20 ] and [ 21 ] (Table 3).
Some of the binding-site occurrences shown in Figure 6are likely to have occurred by chance (especially for sequences that are common in the genome, such as the Hap2/3/4p-, Mig1p-, and Msn2/Msn4p-binding sites).
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