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Example sentences for: binders

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All of the peptide binders showed enrichment of arginine residues, as would be expected for RNA binding proteins.
RNA binding proteins are known to have an overall abundance of certain amino acid residues [ 8 9 ] . Table 4shows a comparison of the specific amino acid composition of peptide binders with regard to their average frequency of occurrence seen within the original unpanned library.
1) are included in regions that have previously been shown together to be sufficient to confer sequence specificity to an HMG-box protein [ 23 ] . Positions 5 and 10 are proline and serine, respectively, in the sequence-independent DNA binders as well as in TOX.
In addition, several peptide binders showed the presence of the RGG box (Figure 2A) and one sequence was found that contained the KH motif (Figure 2B), both of which are known RNA-binding motifs [ 8 9 ] . The isolation of surrogates containing generic RNA binding motifs is not unexpected and probably results from enhanced binding and concomitant enrichment of these peptides during the panning process.
This observation emphasizes the primary goal of structure-based screening procedures, which is to significantly accelerate the initial steps of lead identification projects by automatically discriminating between binders and non-binders, rather than ranking ligands according to their affinity for the receptor.