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Example sentences for: binders

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In addition, several peptide binders showed the presence of the RGG box (Figure 2A) and one sequence was found that contained the KH motif (Figure 2B), both of which are known RNA-binding motifs [ 8 9 ] . The isolation of surrogates containing generic RNA binding motifs is not unexpected and probably results from enhanced binding and concomitant enrichment of these peptides during the panning process.
For each RNA target, the predicted amino acid sequences of the peptide binders were analyzed in terms of both overall amino acid content and the occurrence of known RNA-binding motifs and consensus domains.
All of the peptide binders showed enrichment of arginine residues, as would be expected for RNA binding proteins.
Sequence analysis of surrogate peptide binders to HCV using MEME (Motif Elicitation Program) and other peptide sequence alignment programs identified a consensus sequence TxRLL found in four peptides binding to the HCV mRNA (Figure 5).
RNA binding proteins are known to have an overall abundance of certain amino acid residues [ 8 9 ] . Table 4shows a comparison of the specific amino acid composition of peptide binders with regard to their average frequency of occurrence seen within the original unpanned library.