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Example sentences for: bdnf

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BDNF exon-containing subclones were identified by dot-blot hybridization using digoxigenin-labelled probes prepared from 5' RACE clones by PCR.
We previously cloned a zebrafish BDNF transcript that appeared to contain two exons and thus suggested that the zebrafish and mammalian BDNF genes have similar organizations [ 4 ] . We recently cloned the zebrafish BDNF gene and identified the previously cloned 5' exon in the genomic clone [ 27 ] . The exon was named exon 1c.
In response to nerve injury BDNF mRNA is slowly but substantially increased in Schwann cells and muscle fibers [ 18 ] . BDNF expression is also increased in cardiac myocytes following ischemic injury [ 19 ] .
We detected BDNF mRNA in the muscle layer of the fin of the 4 days old zebrafish larvae using in situ hybridization [ 4 ] , but the identity of the expressing cells has not yet been definitvely established.
The molecular mechanisms that induce BDNF gene expression in muscle during development, maintain basal expression in the adult muscle and dynamically regulate BDNF mRNA in muscle in response to neuromuscular activity and injury are not known.